@article {43212,
	title = {Concise asymmetric route to the antibiotic macrolides patulolide A and pyrenophorin},
	journal = {Tetrahedron Letters},
	volume = {47},
	year = {2006},
	month = {SEP},
	pages = {6623-6626},
	abstract = {In this letter, we describe an enantiospecific route to patulolide A and pyrenophorin through the synthesis of known protected seco acid precursors starting from commercially available (S)-ethyl lactate. (c) 2006 Elsevier Ltd. All rights reserved.},
	doi = {10.1016/j.tetlet.2006.07.026},
	author = {Rao, K. Srinivasa and Reddy, D. Srinivasa and Mukkanti, K. and Pal, Manojit and Iqbal, Javed}
}
@article {48985,
	title = {Comprehensive study on solomonamides: total synthesis, stereochemical revision, and SAR studies toward identification of simplified lead},
	journal = {Journal of Organic Chemistry},
	volume = {88},
	year = {2023},
	month = {DEC },
	pages = {17088-17133},
	type = {Article},
	abstract = {<p>
	Solomonamides, a pair of macrocyclic peptide natural products originating from marine sources, have garnered significant attention within the synthetic community owing to their marked anti-inflammatory efficacy and intricate molecular architectures. In this paper, we present a very detailed investigation into solomonamides, including the challenges associated with the total synthesis, the evolution of our synthetic strategies, structural reassignment, synthesis of all possible stereoisomeric macrocycles, biological assessment, structure-activity relationship (SAR) studies, etc. Within the ambit of this total synthesis, diverse strategies for macrocyclization were rigorously explored, encompassing the Friedel-Crafts acylation, cyclization involving the aniline NH2 moiety, macrolactamization utilizing Gly-NH2, and Heck macrocyclization methodologies. In addition, an array of intriguing chemical transformations were devised, including but not limited to photo-Fries rearrangement, Wacker oxidation, ligand-free Heck macrocyclization, oxidative cleavage of indole, synthesis of contiguous stereocenters via substrate/reagent-controlled protocols, and simultaneous making and breaking of olefinic moieties. The findings of this investigation revealed a structurally simplified lead compound. Remarkably, the lead compound, while possessing structural simplification in comparison to the intricate solomonamide counterparts, demonstrates equipotent in vivo anti-inflammatory efficacy.</p>
},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.3c01987},
	author = {Jachak, Gorakhnath R. and Kashinath, K. and Vasudevan, N. and Athawale, Paresh R. and Choudhury, Rahul and Dange, Santoshkumar S. and Agarwal, Heena and Barthwal, Manoj Kumar and Reddy, D. Srinivasa}
}
