@article { ISI:000364803200005,
	title = {Design, synthesis, and identification of silicon incorporated oxazolidinone antibiotics with improved brain exposure},
	journal = {ACS Medicinal Chemistry Letters},
	volume = {6},
	number = {11},
	year = {2015},
	month = {NOV},
	pages = {1105-1110},
	publisher = {AMER CHEMICAL SOC},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>Therapeutic options for brain infections caused by pathogens with a reduced sensitivity to drugs are limited. Recent reports on the potential use of linezolid in treating brain infections prompted us to design novel compounds around this scaffold. Herein, we describe the design and synthesis of various oxazolidinone antibiotics with the incorporation of silicon. Our findings in preclinical species suggest that silicon incorporation is highly useful in improving brain exposures. Interestingly, three compounds from this series demonstrated up to a 30-fold higher brain/plasma ratio when compared to linezolid thereby indicating their therapeutic potential in brain associated disorders.</p>},
	keywords = {Antibacterial, brain exposure, linezolid, oxazolidinone, sila analogue},
	issn = {1948-5875},
	doi = {10.1021/acsmedchemlett.5b00213},
	author = {Seetharamsingh, B. and Ramesh, Remya and Dange, Santoshkumar S. and Khairnar, Pankaj V. and Singhal, Smita and Upadhyay, Dilip and Veeraraghavan, Sridhar and Viswanadha, Srikant and Vakkalanka, Swaroop and Reddy, D. Srinivasa}
}
@article { ISI:000380599800018,
	title = {Multi-gram scale synthesis of hunanamycin A, an antibiotic natural product from the marine source},
	journal = {Tetrahedron Letters},
	volume = {57},
	number = {32},
	year = {2016},
	month = {AUG},
	pages = {3662-3663},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>A simple, practical, and biomimetic approach to access antibiotic natural product hunanamycin A starting from readily available inexpensive material Riboflavin is disclosed here. The present synthesis consists of three operationally simple, protecting group free steps and it is far superior when compared with the previous route. Using this route one can make multi-gram quantities of the natural product which will help in further biological assays, in particular exploring the potential of treating food infections. (C) 2016 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Antibacterial, Biomimetic synthesis, Gram scale synthesis, Natural product, Riboflavin},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2016.07.003},
	author = {Shingare, Rahul D. and Farhana, Sa Ada and Reddy, D. Srinivasa}
}
