@article { ISI:000366429100003,
	title = {Breaking and making of rings: a method for the preparation of 4-quinolone-3-carboxylic acid amides and the expensive drug ivacaftor},
	journal = {European Journal of Organic Chemistry},
	number = {34},
	year = {2015},
	month = {DEC},
	pages = {7433-7437},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
	abstract = {<p>A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop-Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.</p>},
	keywords = {Amides, Drug design, Fused-ring systems, Oxidation, Ozonolysis},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201501048},
	author = {Vasudevan, N. and Jachak, Gorakhnath R. and Reddy, D. Srinivasa}
}
@article {46820,
	title = {Synthesis of alpha-ketoamides using potassium superoxide (KO2) as an oxidizing agent},
	journal = {Tetrahedron},
	volume = {76},
	year = {2020},
	month = {JUN },
	pages = {131262},
	type = {Article},
	abstract = {<p>A simple and convenient method for the synthesis of alpha-ketoamides by the oxidation of aryl acetamides using potassium superoxide (KO2) as an oxidizing agent is disclosed here. The scope of the developed method is successfully tested with fifteen substrates. In addition, the utility of method has been demonstrated by synthesizing an orexin receptor antagonist, a medicinally interesting compound. (C) 2020 Published by Elsevier Ltd.</p>
},
	keywords = {alpha-Ketoamide, Orexin receptor, Oxidation, Potassium superoxide (KO2)},
	issn = {0040-4020},
	doi = {10.1016/j.tet.2020.131262},
	author = {Vasudevan, N. and Routholla, Ganesh and Illa, Giri Teja and Reddy, D. Srinivasa}
}
