@article { ISI:000276010000034,
	title = {Cytotoxic activity of 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol from Eulophia nuda against human cancer cells},
	journal = {Journal of Ethnopharmacology},
	volume = {128},
	number = {1},
	year = {2010},
	month = {MAR},
	pages = {251-253},
	publisher = {ELSEVIER IRELAND LTD},
	address = {ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND},
	abstract = {<p>Ethnopharmacological relevance: Eulophia nuda L. (Orchidaceae) is a medicinally important terrestrial orchid used for the treatment of tumours and various health problems by the local healers throughout the Western Ghats region in Maharashtra (India). Aim of the study: To isolate the active molecule from Eulophia nuda and to study its cytotoxic potential against human cancer cells. Materials and methods: The crude methanolic extract of Eulophia nuda tubers was fractionated by stepwise gradient of the solvents chloroform-methanol to isolate the pure compound. Isolated pure compound was assessed for its cytotoxic potential against human breast cancer cell lines, MCF-7 and MDA-MB-231 using MTT assay. Structure elucidation of the isolated active compound was carried out by extensive spectroscopic analysis including (1)H NMR, (13)C NMR, NOESY, COSY, LC-MS and IR. Results: The isolated active molecule was identified as phenanthrene derivative 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol. This compound showed good antiproliferative activity against human breast cancer cell lines MCF-7 (91\%) and MDA-MB-231 (85\%) at 1000 mu g/ml concentration. Conclusion: 9,10-Dihydro-2,5-dimethoxyphenanthrene-1,7-diol from Eulophia nuda tubers showed good growth suppressive effect against human cancer cell lines MCF-7 and MDA-MB-231 making it a potential biomolecule against human cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.</p>},
	keywords = {Cytotoxic activity, Eulophia nuda, Phenanthrene derivatives},
	issn = {0378-8741},
	doi = {10.1016/j.jep.2009.12.031},
	author = {Shriram, Varsha and Kumar, Vinay and Kishor, P. B. Kavi and Suryawanshi, Sharad B. and Upadhyay, Ankur K. and Bhat, Manoj K.}
}
@article { ISI:000293403000001,
	title = {Crucial role of ocean-atmosphere coupling on the Indian monsoon anomalous response during dipole events},
	journal = {Climate Dynamics},
	volume = {37},
	number = {1-2},
	year = {2011},
	month = {JUL},
	pages = {1-17},
	publisher = {SPRINGER},
	address = {233 SPRING ST, NEW YORK, NY 10013 USA},
	abstract = {<p>This paper examines an issue concerning the simulation of anomalously wet Indian summer monsoons like 1994 which co-occurred with strong positive Indian Ocean Dipole (IOD) conditions in the tropical Indian Ocean. Contrary to observations it has been noticed that standalone atmospheric general circulation models (AGCM) forced with observed SST boundary condition, consistently depicted a decrease of the summer monsoon rainfall during 1994 over the Indian region. Given the ocean-atmosphere coupling during IOD events, we have examined whether the failure of standalone AGCM simulations in capturing wet Indian monsoons like 1994 can be remedied by including a simple form of coupling that allows the monsoon circulation to dynamically interact with the IOD anomalies. With this view, we have performed a suite of simulations by coupling an AGCM to a slab-ocean model with spatially varying mixed-layer-depth (MLD) specified from observations for the 1994 IOD; as well as four other cases (1983, 1997, 2006, 2007). The specification of spatially varying MLD from observations allows us to constrain the model to observed IOD conditions. It is seen that the inclusion of coupling significantly improves the large-scale circulation response by strengthening the monsoon cross-equatorial flow; leading to precipitation enhancement over the subcontinent and rainfall decrease over south-eastern tropical Indian Ocean-in a manner broadly consistent with observations. A plausible physical mechanism is suggested to explain the monsoonal response in the coupled frame-work. These results warrant the need for improved monsoon simulations with fully coupled models to be able to better capture the observed monsoon interannual variability.</p>},
	keywords = {Anomalous wet Indian monsoons, Indian ocean dipole, Numerical simulation, Ocean-atmosphere coupling},
	issn = {0930-7575},
	doi = {10.1007/s00382-010-0830-2},
	author = {Krishnan, R. and Sundaram, Suchithra and Swapna, P. and Kumar, Vinay and Ayantika, D. C. and Mujumdar, M.}
}
