@article { ISI:000337742600003,
	title = {Ru-catalyzed branched versus linear selective C3-alkylation of 2-aroylbenzofurans with acrylates via C-H activation},
	journal = {Chemistry-A European Journal},
	volume = {20},
	number = {26},
	year = {2014},
	month = {JUN},
	pages = {7884-7889},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY},
	abstract = {<p>The carbonyl-directed C3-H activation and alkylation of 2-aroylbenzo[b]furans with acrylates occurs selectively either in a linear or branched fashion, depending on the catalyst employed; [Ru(p-cymene)Cl-2](2) or Ru(PPh3)(3)Cl-2, respectively. Two alternate pathways-funded upon the differences in steric and electronic preferences of these two complexes-is proposed for the selectivity of linear versus branched products.</p>},
	keywords = {acrylate, benzo[b]furan, branched-selective alkylation, C-H activation, ruthenium},
	issn = {0947-6539},
	doi = {10.1002/chem.201400401},
	author = {Kommagalla, Yadagiri and Srinivas, Kolluru and Ramana, Chepuri V.}
}
@article {45734,
	title = {Electronic control on linear versus branched alkylation of 2-/3-aroylbenzofurans with acrylates: combined DFT and synthetic studies},
	journal = {Chemistry-A European Journal},
	volume = {23},
	year = {2017},
	month = {JUN },
	pages = {7570-7581},
	type = {Article},
	abstract = {<p>Investigations on the factors that govern unusual branched alkylation of 2-aroylbenzofurans with acrylates by Ru-catalyzed carbonyl-directed C-H activation has been carried out by calculating the kinetics associated with the two key steps-the coordination of the acrylate with the intermediate ruthenacycle and the subsequent migratory insertion reaction-studied with the help of DFT calculations. Eight possible orientations for each mode of alkylation have been considered for the calculations. From these calculations, it has been understood that there is a synergistic operation of the steric and electronic effects favoring the branched alkylation. Further DFT investigations on the alkylation of the isomeric 3-aroylbenzofurans indicated a preference for the linear alkylation and this has been verified experimentally. Overall, the observed/calculated complementary selectivity in the alkylation of 2-/3-aroylbenzofurans with acrylates reveals that the substrate-dependent charge distribution of the Ru-C bond in the intermediate ruthenacycle is an important determining factor and thus the current work opens up a new domain of substrate design for controlling regioselectivity.</p>},
	keywords = {acrylates, Alkylation, aroylbenzofuran, C-H activation, Density functional calculations},
	issn = {0947-6539},
	doi = {10.1002/chem.201700643},
	author = {Srinivas, Kolluru and Dangat, Yuvraj and Kommagalla, Yadagiri and Vanka, Kumar and Ramana, Chepuri V.}
}
