@article {46894,
	title = {Novel cilengitide-based cyclic RGD peptides as alpha nu beta(3) integrin inhibitors},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {30},
	year = {2020},
	month = {APR},
	pages = {127039},
	type = {Article},
	abstract = {<p>In this letter, we report a series of five new RGD-containing cyclic peptides as potent inhibitors to alpha nu beta(3) integrin protein. We have incorporated various unnatural lipophilic amino acids into the cyclic RGD framework of cilengitide, which is selective for alpha nu beta(3) integrin. All the newly synthesized cyclic peptides were evaluated in vitro solid phase binding assay and investigated for their binding behaviour towards integrin subtypes. All the cyclic peptides were synthesized in excellent yield following solution-phase coupling strategy. The cyclic RGD peptides 1a-e exhibited IC50 of 9.9, 5.5, 72, 11 and 3.3 nM, respectively, towards a alpha nu beta(3) integrin protein. This finding offers further opportunities for the introduction unusual amino acids into the cyclic peptide framework of cilengitide.</p>
},
	keywords = {Anticancer drugs, Cilengitide, Integrins, RGD cyclicpeptides},
	issn = {0960-894X},
	doi = {10.1016/j.bmcl.2020.127039},
	author = {Meena, Chhuttan L. and Singh, Dharmendra and Weinmueller, Michael and Reichart, Florian and Dangi, Abha and Marelli, Udaya Kiran and Zahler, Stefan and Sanjayan, Gangadhar J.}
}
@article {49941,
	title = {Repurposed ciprofloxacin derivatives as potent autophagic-type anticancer agents},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {130},
	year = {2026},
	month = {JAN },
	pages = {130432},
	type = {Article},
	abstract = {<p>
	Drug repurposing - also known as drug repositioning is a proven strategy for identifying new therapeutic uses for existing and pre-approved drugs with considerable success in recent years. Herein, we report the discovery of a novel class of ciprofloxacin-amino acid conjugates that are dynamically potent against different cancer cell lines. Some of the molecules reported herein displayed a strong anti-proliferative effect on MCF-7 (IC50: 6 mu M). The most active anti-proliferative molecule of this series 7a suppressed the proliferation of HCT116, A549, and MDAMB-231 cancer cell lines. Furthermore, we established that the treatment with 7a leads to DNA damage-mediated autophagic cell death in cancer cells. Our findings suggest that appropriate derivatization of the ciprofloxacin drug can yield promising anti-cancer compounds in easy synthetic operations.</p>
},
	keywords = {Anticancer drugs, Autophagic cell death, ciprofloxacin},
	issn = {0960-894X},
	doi = {10.1016/j.bmcl.2025.130432},
	author = {Gone, Nilu Vijay and Sharma, Tanisha and Joshi, Rakesh and Upreti, Akshita and Santra, Manas and Sanjayan, Gangadhar J.}
}
