@article { ISI:000313235300008,
	title = {4(R/S)-Amino/guanidino-substituted proline peptides: design, synthesis and DNA transfection properties},
	journal = {Chimia},
	volume = {66},
	number = {12, 1},
	year = {2012},
	month = {DEC},
	pages = {936-940},
	publisher = {SWISS CHEMICAL SOC},
	address = {SCHWARZTORSTRASSE 9, CH-3007 BERN, SWITZERLAND},
	abstract = {<p>Collagen is a major structural protein found in the connective tissues of higher organisms and mammals and its biomechanical properties are related to the high thermal stability of its triple helical structure. The primary structure of collagen is composed of the repeating tripeptide motif of Pro-Hyp-Gly, where Hyp is 4R-hydroxy proline. Cationic collagen mimetics consisting of [Pro(X)-Pro(Y)-Gly](6) where Pro(X) and Pro(Y) are 4(R/S)-amino/guanidine proline have been synthesized and shown to form triplexes more stable than the unmodified collagen peptide [Pro-Hyp-Gly](6). The origin of hyperstability is due to conformational pre-organization of proline pucker arising from the electronegativity of the cationic group. These cationic collagen peptides are shown to be effective cell penetrating and plasmid DNA transfecting agents. The results have potential for design of new collagen mimetics for biomaterial applications and efficient cell penetrating agents for drug delivery applications.</p>},
	keywords = {4-Aminoproline peptides, 4-Guanidino proline peptides, Cationic collagen mimetics, Cell penetrating peptides},
	issn = {0009-4293},
	doi = {10.2533/chimia.2012.936},
	author = {Umashankara, M. and Nanda, Manaswini and Sonar, Mahesh and Ganesh, Krishna N.}
}
@article { ISI:000302982000044,
	title = {4(R/S)-Guanidinylprolyl collagen peptides: on-resin synthesis, complexation with plasmid DNA, and the role of peptides in enhancement of transfection},
	journal = {Journal of Organic Chemistry},
	volume = {77},
	number = {8},
	year = {2012},
	month = {APR},
	pages = {4131-4135},
	publisher = {AMER CHEMICAL SOC},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>Chimeric collagen peptides containing cationic 4(R/S)-guanidinylproline are synthesized by in situ amidinylation of 4(R/S)-aminoproline residues. These peptides uniquely enhance the transfection efficiency of GFP-encoded plasmid DNA (pRmHa3-GFP) into cells through efficient DNA condensation resulting from nonspecific electrostatic interactions of cationic guanidino groups and localize in subcytoplasmic organelles.</p>},
	issn = {0022-3263},
	doi = {10.1021/jo300070p},
	author = {Nanda, Manaswini and Ganesh, Krishna N.}
}
