@article { ISI:000229223600004,
	title = {Conformationally constrained PNA analogues: structural evolution toward DNA/RNA binding selectivity},
	journal = {Accounts of Chemical Research},
	volume = {38},
	number = {5},
	year = {2005},
	month = {MAY},
	pages = {404-412},
	publisher = {AMER CHEMICAL SOC},
	type = {Article},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>Since its discovery 12 years ago, aminoethylglycyl peptide nucleic acid (aeg-PNA) has emerged as one of the successful DNA mimics for potential therapeutic and diagnostic applications. An important requisite for in vivo applications that has received inadequate attention is engineering PNA analogues for able discrimination between DNA and RNA as binding targets. Our approach toward this aim is based on structural preorganization of the backbone to hybridization-competent conformations to impart binding selectivity. This strategy has allowed us to design locked PNAs to achieve specific hybridization with DNA or RNA with aims to increase the binding strength without losing the binding specificity. This Account presents results of our rationale in design of different conformationally constrained PNA analogues, their synthesis, and evaluation of hybridization specificities.</p>},
	issn = {0001-4842},
	doi = {10.1021/ar030277e},
	author = {Kumar, VA and Ganesh, Krishna N.}
}
@article { ISI:000253646700006,
	title = {Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties},
	journal = {Tetrahedron Letters},
	volume = {49},
	number = {8},
	year = {2008},
	month = {FEB},
	pages = {1314-1318},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	type = {Article},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>The synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-N{\textquoteright}-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer. (c) 2008 Elsevier Ltd. All rights reserved.</p>},
	keywords = {cyanuryl PNA, PNA},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2007.12.095},
	author = {Vysabhattar, Raman and Ganesh, Krishna N.}
}
