@article { ISI:000303366000001, title = {Polymorphs, salts, and cocrystals: what{\textquoteright}s in a name?}, journal = {Crystal Growth \& Design}, volume = {12}, number = {5}, year = {2012}, month = {MAY}, pages = {2147-2152}, publisher = {AMER CHEMICAL SOC}, address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA}, abstract = {

The December 2011 release of a draft United States Food and Drug Administration (FDA) guidance concerning regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredients (APIs) addressed two matters of topical interest to the crystal engineering and pharmaceutical science communities: (1) a proposed definition of cocrystals; (2) a proposed classification of pharmaceutical cocrystals as dissociable {\textquoteleft}{\textquoteleft}API-excipient{\textquoteright}{\textquoteright} molecular complexes. The Indo U.S. Bilateral Meeting sponsored by the Indo-U.S. Science and Technology Forum titled The Evolving Role of Solid State Chemistry in Pharmaceutical Science was held in Manesar near Delhi, India, from February 2-4, 2012. A session of the meeting was devoted to discussion of the FDA guidance draft. The debate generated strong consensus on the need to define cocrystals more broadly and to classify them like salts. It was also concluded that the diversity of API crystal forms makes it difficult to classify solid forms into three categories that are mutually exclusive. This perspective summarizes the discussion in the Indo-U.S. Bilateral Meeting and includes contributions from researchers who were not participants in the meeting.

}, issn = {1528-7483}, doi = {10.1021/cg3002948}, author = {Aitipamula, Srinivasulu and Banerjee, Rahul and Bansal, Arvind K. and Biradha, Kumar and Cheney, Miranda L. and Choudhury, Angshuman Roy and Desiraju, Gautam R. and Dikundwar, Amol G. and Dubey, Ritesh and Duggirala, Nagakiran and Ghogale, Preetam P. and Ghosh, Soumyajit and Goswami, Pramod Kumar and Goud, N. Rajesh and Jetti, Ram R. K. R. and Karpinski, Piotr and Kaushik, Poonam and Kumar, Dinesh and Kumar, Vineet and Moulton, Brian and Mukherjee, Arijit and Mukherjee, Gargi and Myerson, Allan S. and Puri, Vibha and Ramanan, Arunachalam and Rajamannar, T. and Reddy, C. Malla and Rodriguez-Hornedo, Nair and Rogers, Robin D. and Row, T. N. Guru and Sanphui, Palash and Shan, Ning and Shete, Ganesh and Singh, Amit and Sun, Changquan C. and Swift, Jennifer A. and Thaimattam, Ram and Thakur, Tejender S. and Thaper, Rajesh Kumar and Thomas, Sajesh P. and Tothadi, Srinu and Vangala, Venu R. and Variankaval, Narayan and Vishweshwar, Peddy and Weyna, David R. and Zaworotko, Michael J.} } @article { ISI:000306942300059, title = {Polymorphs, salts and cocrystals: what{\textquoteright}s in a name? (vol 12, pg 2147, 2012)}, journal = {Crystal Growth \& Design}, volume = {12}, number = {8}, year = {2012}, month = {AUG}, pages = {4290-4291}, publisher = {AMER CHEMICAL SOC}, address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA}, issn = {1528-7483}, doi = {10.1021/cg300704b}, author = {Aitipamula, Srinivasulu and Banerjee, Rahul and Bansal, Arvind K. and Biradha, Kumar and Cheney, Miranda L. and Choudhury, Angshuman Roy and Desiraju, Gautam R. and Dikundwar, Amol G. and Dubey, Ritesh and Duggirala, Nagakiran and Ghogale, Preetam P. and Ghosh, Soumyajit and Goswami, Pramod Kumar and Goud, N. Rajesh and Jetti, Ram R. K. R. and Karpinski, Piotr and Kaushik, Poonam and Kumar, Dinesh and Kumar, Vineet and Moulton, Brian and Mukherjee, Arijit and Mukherjee, Gargi and Myerson, Allan S. and Puri, Vibha and Ramanan, Arunachalam and Rajamannar, T. and Reddy, C. Malla and Rodriguez-Hornedo, Nair and Rogers, Robin D. and Row, T. N. Guru and Sanphui, Palash and Shan, Ning and Shete, Ganesh and Singh, Amit and Sun, Changquan C. and Swift, Jennifer A. and Thaimattam, Ram and Thakur, Tejender S. and Thaper, Rajesh Kumar and Thomas, Sajesh P. and Tothadi, Srinu and Vangala, Venu R. and Vishweshwar, Peddy and Weyna, David R. and Zaworotko, Michael J.} } @article {49390, title = {Template-asisted visible light-induced [2+2] photodimerization in a pseudopolymorphic binary solid: topotactic transformation vs photoinduced crystal melting}, journal = {CRYSTAL GROWTH \& DESIGN}, volume = {24}, year = {2024}, month = {MAY }, pages = {5193-5199}, type = {Journal Article}, keywords = {CATION-PI INTERACTIONS, SINGLE-CRYSTAL, STATE PHOTODIMERIZATION, Supramolecular}, issn = {1528-7483}, doi = {10.1021/acs.cgd.4c00426}, author = {Ahsan, Mollah Rohan and Varma, Harshit and Mishra, Manish Kumar and Mukherjee, Arijit} } @article {49708, title = {Photo-induced cracking in a Bi-component molecular solid: capturing structural intermediates}, journal = {Chemistry-An Asian Journal}, volume = {20}, year = {2025}, month = {MAY}, type = {Article}, abstract = {

A photo-responsive bi-component solid is designed based on robust large synthons. The study not only provides a template-based approach for a system that was difficult to photo-dimerize, but the designed solid also leads to photo-induced cracking upon photodimerization. The delicate structural design helps in capturing the structural intermediates, which reveals a possible reorientation of the photodimer within the crystal to maintain structural integrity.

}, keywords = {bi-component solid, crystal engineering, photoinduced cracking, single-crystal-to-single crystal transformation, [2+2] photodimerization}, issn = {1861-4728}, doi = {10.1002/asia.202401518}, author = {Ahsan, Mollah Rohan and Mishra, Manish Kumar and Mukherjee, Arijit} } @article {50042, title = {Exploring the role of large synthons in the design of bicomponent salts of cimetidine}, journal = {Crystal Growth \& Design}, volume = {26}, year = {2026}, month = {FEB }, pages = {1875-1884}, type = {Article}, abstract = {

Cimetidine, a popular histamine H2-receptor antagonist, represents a complex structural landscape exhibiting multiple forms. Attempts to synthesize a bicomponent salt with fumaric acid suffered from crystallization challenges in the past, especially toward the growth of anhydrous single crystals. In this work, we address these crystallization challenges by adopting an alternative crystallization approach involving ionic liquids and analyzing the structural landscape with a large synthon-based approach. Two novel forms of cimetidine fumarate were isolated. The structural differences in the forms of cimetidine fumarate were further explored by using different coformers as structural probes.

}, issn = {1528-7483}, doi = {10.1021/acs.cgd.5c01761}, author = {Khatun, Saheba and Sar, Bandana and Hosmani, Girish Siddanagouda and Mishra, Manish Kumar and Ravi, Punna Rao and Mukherjee, Arijit} }