@article {49699,
	title = {Desymmetrization of myo-inositol},
	journal = {Carbohydrate Research},
	volume = {553},
	year = {2025},
	month = {JUL},
	pages = {109505},
	type = {Article},
	abstract = {<p>
	Chemistry and biology of phosphoinositols have been intensely investigated areas of research over the last 4-5 decades due to their involvement in cellular signal transduction pathways. Efficient laboratory synthesis of enantiomeric derivatives of inositols was a central issue since they were required for the delineation of the myo-inositol cycle as well as for the total synthesis of polyol based natural products and their derivatives. This essentially meant the development of competent methods for the desymmetrization of myo-inositol leading to the preparation of enantiomeric O-substituted derivatives of myo-inositol. This was approached by: the classical resolution methods involving separable diastereomers, the chiral pool synthesis, enzyme catalysis, asymmetric catalysis and preferential crystallization of enantiomers in a racemic conglomerate. This review summarizes results obtained in author{\textquoteright}s laboratory, as well as those reported in the literature on attempts at desymmetrization of myo-inositol.</p>
},
	keywords = {Conglomerate, Crystallization, Cyclitol, Enantiomers, Inositol, Lipid},
	issn = {0008-6215},
	doi = {10.1016/j.carres.2025.109505},
	author = {Patil, Nivedita T. and Patil, Madhuri T. and Gonnade, Rajesh G. and Shashidhar, Mysore S.}
}
