@article { ISI:000348510400004,
	title = {Catalyst-dependent selectivity in the relay catalytic branching cascade},
	journal = {Chemistry-A European Journal},
	volume = {21},
	number = {6},
	year = {2015},
	month = {FEB},
	pages = {2319-2323},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY},
	abstract = {<p>The synthesis of small organic molecules as probes for discovering new therapeutic agents has been an important aspect of chemical biology. One of the best ways to access collections of small molecules is to use various techniques in diversity-oriented synthesis (DOS). Recently, a new form of DOS, namely relay catalytic branching cascades (RCBCs), has been introduced, wherein a common type of starting material reacts with several scaffold-building agents (SBAs) to obtain structurally diverse molecular scaffolds under the influence of catalysts. Herein, the RCBC reaction of a common type of substrate with SBAs is reported to give two different types of molecular scaffolds and their formation is essentially dependent on the type of catalyst used.</p>},
	keywords = {alkynols, cascade synthesis, chemoselectivity, diversity-oriented synthesis, Homogeneous catalysis},
	issn = {0947-6539},
	doi = {10.1002/chem.201405736},
	author = {Bansode, Avinash H. and Shaikh, Aslam C. and Kavthe, Rahul D. and Thorat, Shridhar and Gonnade, Rajesh G. and Patil, Nitin T.}
}
@article {49322,
	title = {Manganese-catalyzed chemoselective direct hydrogenation of α,β-epoxy ketones and α-ketoamides at room temperature},
	journal = {Advanced Synthesis \& Catalysis},
	volume = {366},
	year = {2024},
	month = {AUG},
	pages = {3338-3345},
	type = {Article},
	abstract = {<p>
	Chemoselective hydrogenation of alpha,beta-epoxy ketones and alpha-ketoamides is achieved at room temperature (25 degrees C) using 2.0 bar H-2 and a pincer-ligated Mn(I) catalyst that provides synthetically valuable alpha-hydroxy epoxides and alpha-hydroxy amides. This protocol applies to a wide range of alkyl- and aryl-substituted alpha,beta-epoxy ketones, including terpenes (alpha-ionone, nootkatone, and R-carvone)- and steroids (testosterone and progesterone)-derived epoxy ketones, and tolerates H-2 sensitive functionalities, such as halides, acetyl, nitrile, nitro, epoxide, alkenyl and alkynyl groups. Additionally, alpha-ketoamides bearing reducible functional groups, including acetyl and diazo benzene, were untouched under this protocol and selectively converted to alpha-hydroxy amides. A preliminary mechanistic study highlighted the metal-ligand cooperative H-2 activation process.</p>
},
	keywords = {alpha, beta-epoxy ketones, chemoselectivity, direct hydrogenation, manganese, Metal-ligand cooperation},
	issn = {1615-4150},
	doi = {10.1002/adsc.202400267},
	author = {Shabade, Anand B. and Singh, Rahul K. and Gonnade, Rajesh G. and Punji, Benudhar}
}
