@article { ISI:000313764300025,
	title = {Proteomic study reveals downregulation of apolipoprotein A1 in plasma of poorly controlled diabetes: a pilot study},
	journal = {Molecular Medicine Reports},
	volume = {7},
	number = {2},
	year = {2013},
	month = {FEB},
	pages = {495-498},
	publisher = {SPANDIDOS PUBL LTD},
	address = {POB 18179, ATHENS, 116 10, GREECE},
	abstract = {<p>Proteomic approaches aid in gaining a better understanding of the pathophysiology of diabetic complications. In view of this, differential protein expression in diabetic plasma samples was studied by a combination of proteomic and western blot analyses. Diabetic plasma samples were categorized based on glycated haemoglobin levels as controlled diabetes (CD; 7-8\%), poorly controlled diabetes (PCD; \&gt;8\%) and non-diabetic control (ND;\&lt;6.4\%). Two-dimensional electrophoresis and liquid chromatography-mass spectrometry revealed differential expression of proteins including upregulation of fibrinogen and haptoglobin and downregulation of vitamin D binding protein, alpha-1-antitrypsin, transthyretin and apolipoprotein A1 (Apo A1) in diabetic compared with non-diabetic plasma samples. Amongst these proteins, Apo A1 downregulation was prominent in PCD. Downregulation of Apo A1 may serve as an early predictive marker of diabetic complications.</p>},
	keywords = {biomarker, HbA1c, proteomics},
	issn = {1791-2997},
	doi = {10.3892/mmr.2012.1223},
	author = {Bhonsle, Hemangi S. and Korwar, Arvind M. and Chougale, Ashok D. and Kote, Sachin S. and Dhande, Nitin L. and Shelgikar, Kishore M. and Kulkarni, Mahesh J.}
}
