@article {44095,
	title = {Dry molten globule-like intermediate during the base-induced unfolding of a multidomain protein},
	journal = {Physical Chemistry Chemical Physics},
	volume = {19},
	year = {2017},
	month = {NOV},
	pages = {30207-30216},
	type = {Article},
	abstract = {The nature of the initial structural events during the base-induced unfolding of the native (N) state of proteins is poorly understood. Combining site-specific fluorescence resonance energy transfer, size exclusion chromatography, dynamic fluorescence quenching, red-edge excitation shift and circular dichroism spectroscopy, we show here that an early intermediate during the base-induced unfolding of a multidomain protein, i.e., the B form, has features of a dry molten globule. We show that the N (sic) B transition involves protein expansion and loosening of packing of inter-domain helices near domains I and II without the disruption of intra-domain packing or any change in hydration of the inter-domain region which resembles a molten hydrocarbon. Surprisingly, the disruption of inter-domain packing accounts for 40-45\% of the total change in free energy of complete unfolding. Our results show that the disruption of van der Waals packing can be decoupled in different regions of a protein and could occur prior to hydrophobic solvation during base-induced unfolding, challenging the existing notion.},
	doi = {10.1039/c7cp06614g},
	author = {Acharya, Nirbhik and Mishra, Prajna and Jha, Santosh Kumar}
}
@article {46274,
	title = {Dry molten globule-like intermediate during the base-induced unfolding of a multidomain protein (vol 19, pg 20307, 2017)},
	journal = {Physical Chemistry Chemical Physics},
	volume = {21},
	year = {2019},
	month = {SEP},
	pages = {20499-20499},
	type = {Correction},
	doi = {10.1039/c9cp90219h},
	author = {Acharya, Nirbhik and Mishra, Prajna and Jha, Santosh Kumar}
}
