@article { ISI:000321965300043,
	title = {Biosynthesis of antinutritional alkaloids in solanaceous crops is mediated by clustered genes},
	journal = {Science},
	volume = {341},
	number = {6142},
	year = {2013},
	month = {JUL},
	pages = {175-179},
	publisher = {AMER ASSOC ADVANCEMENT SCIENCE},
	address = {1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA},
	abstract = {<p>Steroidal glycoalkaloids (SGAs) such as alpha-solanine found in solanaceous food plants-as, for example, potato-are antinutritional factors for humans. Comparative coexpression analysis between tomato and potato coupled with chemical profiling revealed an array of 10 genes that partake in SGA biosynthesis. We discovered that six of them exist as a cluster on chromosome 7, whereas an additional two are adjacent in a duplicated genomic region on chromosome 12. Following systematic functional analysis, we suggest a revised SGA biosynthetic pathway starting from cholesterol up to the tetrasaccharide moiety linked to the tomato SGA aglycone. Silencing GLYCOALKALOID METABOLISM 4 prevented accumulation of SGAs in potato tubers and tomato fruit. This may provide a means for removal of unsafe, antinutritional substances present in these widely used food crops.</p>},
	issn = {0036-8075},
	doi = {10.1126/science.1240230},
	author = {Itkin, M. and Heinig, U. and Tzfadia, O. and Bhide, Amey J. and Shinde, B. and Cardenas, Pablo D. and Bocobza, S. E. and Unger, T. and Malitsky, Sergey and Finkers, R. and Tikunov, Y. and Bovy, A. and Chikate, Y. and Singh, P. and Rogachev, I. and Beekwilder, J. and Giri, Ashok P. and Aharoni, Asaph}
}
