@article { ISI:000377425900059,
	title = {Problem solving and environmentally benign approach toward diversity oriented synthesis of novel 2-amino-3-phenyl (or Alkyl) sulfonyl-4H-chromenes at ambient temperature},
	journal = {ACS Sustainable Chemistry \& Engineering},
	volume = {4},
	number = {6},
	year = {2016},
	month = {JUN},
	pages = {3450-3464},
	publisher = {AMER CHEMICAL SOC},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>A problem solving, environmentally benign, and diversity oriented protocol has been described for multi component synthesis of medicinally privileged 2-amino-3-phenyl (or methyl) sulfonyl-4H-chromenes by one-pot, three component condensation among aldehydes, phenyl (or methyl) sulphonyl acetonitrile, and alpha-naphthol, 3-dimethylamino phenol, 4-hydroxy-N-methyl-quinoline-2-one as well as 4-hydroxycarbazole, using diethylamine as an efficient organo catalyst. The catalyst employed is commercially available, inexpensive, and nontoxic. Ambient reaction conditions, very high yields, wide scope, and avoidance of conventional isolation as well as chromatographic purification have improved the practical utility of this protocol manifold.</p>},
	keywords = {2-Amino-3-methylsulfonyl-4H-chromenes, 2-Amino-3-phenylsulfonyl-4H-chromenes, diethylamine, green chemistry, Multicomponent synthesis, organocatalyst},
	issn = {2168-0485},
	doi = {10.1021/acssuschemeng.6b00484},
	author = {Pandit, Kapil S. and Kupwade, Ravindra V. and Chavan, Pramod V. and Desai, Uday V. and Wadgaonkar, Prakash P. and Kodam, Kisan M.}
}
@article {46154,
	title = {Click chemistry based multicomponent approach in the synthesis of spirochromenocarbazole tethered 1,2,3-triazoles as potential anticancer agents},
	journal = {Bioorganic Chemistry},
	volume = {85},
	year = {2019},
	month = {APR},
	pages = {475-486},
	type = {Article},
	abstract = {<p>A series of spirochromenocarbazole tethered 1,2,3-triazoles were synthesized via click chemistry based one-pot, five component reaction between N-propargyl isatins, malononitrile, 4-hydroxycarbazole, aralkyl halides and sodium azide using cellulose supported CuI nanoparticles (Cell-CuI NPs) as the heterogeneous catalyst. Antiproliferative activity of all the synthesized compounds was investigated against panel of cancer cell lines such as MCF-7, MDA-MB-231, HeLa, PANG-1, A-549, and THP-1. Many of the synthesized compounds exhibited good anti-proliferative activity against breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cells with IC50 values less than 10 mu M. In case of MCF-7 cells, among the nine compounds that showed good anti-proliferative activity, compounds 6f and 6j were found to be highly potent (IC50 , = 2.13 mu M and 4.80 mu M, respectively). In case of MDA-MB-231, three compounds (6k, 6j and 6s) showed antiproliferative activity amongst which 6k was the most potent one (IC50 = 3.78 mu M). On the other hand, in cervical cancer HeLa cells, compounds 6b, 6g, 6s and 6u showed excellent antiproliferative activity (IC50 = 4.05, 3.54, 3.83, 3.35 mu M, respectively). All the compounds were found to be nontoxic to the human umbilical vein endothelial cells (HUVECs). AO and EtBr staining and fluorescence microscopy studies of the active compounds (IC50 \&lt; 5 mu M) suggested that these compounds induce cell death by apoptosis.</p>
},
	keywords = {1, 2, 3-Triazolylspirochromenocarbazole, Anticancer, Apoptotic assay, Click chemistry, Cytotoxicity, heterogeneous catalysis, Multicomponent synthesis},
	issn = {0045-2068},
	doi = {10.1016/j.bioorg.2019.01.070},
	author = {Chavan, V, Pramod and Desai, V, Uday and Wadgaonkar, Prakash P. and Tapase, Savita R. and Kodam, Kisan M. and Choudhari, Amit and Sarkar, Dhiman}
}
