@article { ISI:000371344600012,
	title = {Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {26},
	number = {7},
	year = {2016},
	month = {APR},
	pages = {1704-1708},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>We have developed, highly efficient, one-pot, solvent-free, [Et3NH][HSO4] catalyzed multicomponent reaction protocol for the synthesis of 1,3-thiazolidin-4-ones in excellent yields. For the first time, the 1,3-thiazolidin-4-ones were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis dormant MTB H37Ra and Mycobacterium bovis BCG strains. Among the synthesized basic 1,3-thiazolidin-4-ones, particularly the compounds 4c, 4d, 4e, 4f, 4h, 4i and 4j displays promising antitubercular activity along with no significant cytotoxicity against the cell lines MCF-7, A549 and HCT-116. (C) 2016 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Antitubercular, Cytotoxicity, Green protocol, Multicomponent reaction},
	issn = {0960-894X},
	doi = {10.1016/j.bmcl.2016.02.056},
	author = {Subhedar, Dnyaneshwar D. and Shaikh, Mubarak H. and Arkile, Manisha A. and Yeware, Amar and Sarkar, Dhiman and Shingate, Bapurao B.}
}
@article { ISI:000373993600011,
	title = {Facile synthesis of new N-sulfonamidyl-4-thiazolidinone derivatives and their biological evaluation},
	journal = {New Journal of Chemistry},
	volume = {40},
	number = {4},
	year = {2016},
	month = {FEB},
	pages = {3047-3058},
	publisher = {ROYAL SOC CHEMISTRY},
	address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND},
	abstract = {<p>The one-pot three-component syntheses of new N-sulfonamide-thiazolidin-4-one derivatives were carried out in excellent yield using [HDBU][HSO4] as an ionic liquid under solvent-free conditions. The newly synthesized compounds were screened against fungal strains and a number of compounds were seen to display excellent antifungal activity. In addition, the synthesized compounds were screened for their scavenging activity of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and showed very good antioxidant activity. Finally, theoretical predictions derived from molecular docking studies against the potential target sterol 14 alpha-demethylase (CYP51) helped establish a link between the observed biological activity and the binding affinity, thereby providing insights into the specific bonding and non-bonding interactions governing the activity.</p>},
	issn = {1144-0546},
	doi = {10.1039/c6nj00021e},
	author = {Subhedar, Dnyaneshwar D. and Shaikh, Mubarak H. and Khan, Firoz A. Kalam and Sangshetti, Jaiprakash N. and Khedkar, Vijay M. and Shingate, Bapurao B.}
}
@article {44476,
	title = {Facile and solvent-free domino synthesis of new quinolidinyl-2,4-thiazolidinones: antifungal activityand molecular docking},
	journal = {Mini-Reviews in Medicinal Chemistry},
	volume = {18},
	year = {2018},
	month = {JAN},
	pages = {622-630},
	abstract = {Objective: We have synthesized new quinolidinyl-thiazolidinones via Knoevenagel condensation-alkylation reaction, catalyzed by [Et3NH][HSO4]. The present approach offers several advantages such as higher yields, eco-friendly reaction condition and economic availability of the catalyst. 

Method: The newly synthesized compounds were evaluated for their in vitro antifungal activity against six fungal strains. Some of the synthesized conjugates displayed good to moderate antifungal activity. 

Conclusion: Again, the molecular docking study performed against the fungal sterol 14 alpha-demethylase (CYP51) showed an excellent binding affinity towards the enzyme which could rationalize the promising antifungal activity portrayed by these derivatives and provides a platform for structure based drug design.},
	doi = {10.2174/1389557516666161226161152},
	author = {Subhedar, Dnyaneshwar D. and Shaikh, Mubarak H. and Tupe, Santosh G. and Deshpande, Mukund V. and Khedkar, Vijay M. and Jha, Prakash C. and Shingate, Bapurao B.}
}
