@article {48104,
	title = {Process development for crystalline xylitol production from corncob biomass by Pichia caribbica},
	journal = {Food and Bioproducts Processing},
	volume = {133},
	year = {2022},
	month = {MAY},
	pages = {45-56},
	type = {Article},
	abstract = {<p>
	Xylitol, a commodity chemical, is widely used in nutraceutical and pharmaceutical formulations. Microbial xylitol production is a promising alternative to mitigate current industrial practice issues and offers an environment-friendly sustainable conversion route. This study demonstrates a bioprocess for xylitol production from corncob using a mesophilic yeast Pichia caribbica. Corncob was hydrolyzed by dilute acid and steam explosion to recover fermentable xylose and used as the feed for xylitol production. Activated carbon treatment (3\% w/v) completely removed the biomass-derived inhibitors furfural and hydroxymethyl furfural from the liquid hydrolysate. The fermenting yeast Pichia caribbica produced 124.1 +/- 0.45 g/L xylitol from the detoxified and concentrated corncob hydrolysate with a high yield of 0.80 +/- 0.02 g/g. The crystallized xylitol with 96.5\% purity demonstrated no harmful effects on the cell line used as a control for the in-vitro toxicity studies. This proof of concept can be applied to help scale up for bio-refinery-based large-scale production of xylitol from corncob biomass.(c) 2022 Institution of Chemical Engineers. Published by Elsevier Ltd. All rights reserved.</p>
},
	keywords = {Biomass, Corncob, Detoxification, Fermentation, Toxicity analysis, xylitol},
	issn = {0960-3085},
	doi = {10.1016/j.fbp.2022.02.006},
	author = {Dasgupta, Diptarka and Sidana, Arushdeep and Sarkar, Bipul and More, Snehal and Ghosh, Debashish and Bhaskar, Thallada and Ray, Anjan}
}
@article {47762,
	title = {Process development for detoxification of corncob hydrolysate using activated charcoal for xylitol production},
	journal = {Journal of Environmental Chemical Engineering},
	volume = {10},
	year = {2022},
	month = {FEB},
	pages = {107097},
	type = {Article},
	abstract = {The work describes process development for detoxification of corncob hydrolysate using activated carbon for microbial xylitol production. Activated carbon was used as an adsorbent to completely remove the major fermentation inhibitors obtained during dilute acid and steam explosion of biomass. A xylitol yield of 0.78 g/g was achieved from the detoxified hydrolysate in a 5 L fermenter by Pichia caribbica. The spent carbon was effectively regenerated and used for three consecutive cycles of operation. The successive regeneration and reuse of carbon could reduce the operational cost by similar to 38\% and be used as a reference dataset for process scale-up and cost-effective xylitol production.},
	keywords = {Activated charcoal, Detoxification, Fermentation, Regeneration, xylitol},
	issn = {2213-2929},
	doi = {10.1016/j.jece.2021.107097},
	author = {Ahuja, Vishal and Kshirsagar, Siddheshwar and Ghosh, Prasenjit and Sarkar, Bipul and Sutar, Ajit and More, Snehal and Dasgupta, Diptarka}
}
