@article { ISI:000345902500007,
	title = {Facile and convenient synthesis of (+/-)-Biotin via MgCl2/Et3N-mediated C-C coupling and mitsunobu reaction},
	journal = {Synlett},
	volume = {25},
	number = {20},
	year = {2014},
	month = {DEC},
	pages = {2879-2882},
	publisher = {GEORG THIEME VERLAG KG},
	type = {Article},
	address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY},
	abstract = {<p>A synthesis of (+/-)-biotin is described starting from simple starting materials viz. cyclohexanone and amino malonic acid ester. The key steps involved are MgCl2/Et3N coupling of amino malonic acid ester derivative and acid chloride, Mitsunobu reaction, ozonolysis, Staudinger reduction, novel urea formation, and subsequent dibenzylation. This approach is economical and involves high-yielding steps and simple reaction conditions.</p>},
	keywords = {Appel reaction, biotin, Mitsunobu reaction, Ozonolysis, Staudinger reduction},
	issn = {0936-5214},
	doi = {10.1055/s-0034-1379365},
	author = {Chavan, Subhash P. and Chavan, Prakash N. and Lasonkar, Pradeep B. and Khairnar, Lalit B. and Kadam, Appasaheb L.}
}
@article {46992,
	title = {Furan-derived chiral bicycloaziridino lactone synthon: collective syntheses of oseltamivir phosphate (Tamiflu), (S)-pipecolic acid and its 3-hydroxy derivatives},
	journal = {Chemistry-An Asian Journal},
	volume = {15},
	year = {2020},
	month = {FEB },
	pages = {415-424},
	type = {Article},
	abstract = {<p>A unified synthetic strategy for oseltamivir phosphate (tamiflu), (S)-pipecolic acid, and its 3-hydroxy derivatives from furan derived common chiral bicycloaziridino lactone synthon is described here. Key features are the short (4-steps), enantiopure, and decagram-scale synthesis of common chiral synthon from furan and its first-ever application in the total synthesis of biologically active compounds by taking the advantages of high functionalization ability of chiral synthon.</p>
},
	keywords = {Aziridine synthon, Chiral auxiliary, collective synthesis, Pipecolic acid, Tamiflu},
	issn = {1861-4728},
	doi = {10.1002/asia.201901523, Early Access Date = JAN 2020},
	author = {Chavan, Subhash P. and Kadam, Appasaheb L. and Shinde, Shrikrishna S. and Gonnade, Rajesh G.}
}
@article {47664,
	title = {Formal synthesis of (-)-quinagolide: diastereoselective ring expansion via a bicyclic aziridinium ion strategy to access the octahydrobenzo[g]quinoline architecture},
	journal = {Journal of Organic Chemistry},
	volume = {86},
	year = {2021},
	month = {JUL },
	pages = {9344-9352},
	type = {Article},
	abstract = {The diastereoselective formal synthesis of (-)-quinagolide, a D-2 receptor agonist, has been achieved. The synthesis started from L-pyroglutamic acid and relied on utilization of (a) a stereospecific catalytic hydrogenation and diastereoselective Horner-Emmons-Michael cascade to obtain functionalized prolinate, (b) a Lewis acid mediated Pummerer cyclization to construct a tricyclic fused ring system, and (c) a diastereoselective ring expansion via a bicyclic aziridinium intermediate to access the required 3-substituted piperidine scaffold.},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.1c00603},
	author = {Chavan, Subhash P. and Kawale, Sanket A. and Pisal, Mahesh M. and Kadam, Appasaheb L. and Gonnade, Rajesh G.}
}
