@article {50200,
	title = {Dearomative domino approach for stereoselective construction of functionalized bridged [4.3.1] bicycles},
	journal = {Organic Letters},
	volume = {28},
	year = {2026},
	month = {JUN},
	pages = {8142-8147},
	type = {Article},
	abstract = {<p>
	We report a dearomative (5+2) cycloaddition/oxa-Michael addition cascade strategy that enables concise construction of functionalized bridged [4.3.1] bicyclic frameworks. This base-mediated, one-pot process reveals an unconventional reactivity mode of alpha-arylidene pyrazolones, wherein they function as C2 synthons in dearomative addition to oxidopyrylium intermediates derived from readily accessible acylated pyranones, affording oxygen-bridged [4.3.1] bicycles bearing four stereocenters with excellent diastereocontrol. DFT studies firmly establish the operative reaction pathway and indicate (3+3) spiroannulation as a crucial competing process consistent with the experimental findings.</p>
},
	issn = {1523-7060},
	doi = {10.1021/acs.orglett.6c02076},
	author = {Kaur, Ravneet and Pandya, Rinu and Vanka, Kumar and Singh, Ravi P.}
}
