@article {50089,
	title = {Divergent synthesis of meyers{\textquoteright} lactams and medium lactams via cyclocondensation of γ-ylidene-butanolides with chiral amino alcohols},
	journal = {Journal of Organic Chemistry},
	volume = {91},
	year = {2026},
	month = {APR},
	pages = {5138-5158},
	type = {Article},
	abstract = {<p>
	A novel methodology for constructing Meyers{\textquoteright} lactams (pyrrolidino-oxazolidines), related to biologically potent natural and synthetic scaffolds, has been developed via an unprecedented tandem cyclocondensation of chiral 2-amino alcohols and gamma-ylidene-butanolides. The process proceeds through the initial formation of an ene-lactam intermediate, followed by a Bro/nsted acid (PPTS)-catalyzed ring closure. Under stoichiometric amounts of a Lewis acid (TiCl4), the same set of building blocks affords medium lactams featuring eight-membered ring systems with an exo-enol ether segment. This divergent synthetic strategy enables the efficient generation of a library of Meyers{\textquoteright} lactams and medium lactams with good yields and diastereoselectivity.</p>
},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.6c00086},
	author = {Sadanande, Megha V. and Sharma, Paridhi and Gonnade, Rajesh G. and Kontham, Ravindar}
}
