@article {44654,
	title = {First total synthesis of the proposed structure of pandangolide 1},
	journal = {European Journal of Organic Chemistry},
	year = {2018},
	month = {JUL},
	pages = {3352-3364},
	abstract = {<p>The first total synthesis of the proposed structure of pandangolide 1 is reported. The synthesis was carried out using both an organocatalytic approach and a chiral-pool approach. The required stereochemistry at C-3 and C-5 was installed by using an organocatalytic aldol reaction and a stereoselective ketone reduction. The construction of the 12-membered core was achieved by 2-methyl-6-nitrobenzoic anhydride-mediated Shiina lactonization. The structure of target molecule was confirmed unambiguously by single-crystal X-ray analysis, but the optical rotation and NMR spectroscopic data of the synthetic pandangolide 1 were found to be inconsistent with the natural product.</p>},
	keywords = {lactones, Macrocycles, Natural products, structure elucidation, synthesis design, Total synthesis},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201800675},
	author = {Show, Krishanu and Gonnade, Rajesh G. and Kumar, Pradeep}
}
