@article {49928,
	title = {Supramolecular self-assembly of glochidonol: a renewable triterpenoid from glochidion tomentosum},
	journal = {Chemistryselect},
	volume = {10},
	year = {2025},
	month = {AUG },
	pages = {e01207},
	type = {Article},
	abstract = {<p>
	Glochidonol a lupane pentacyclic (6-6-6-6-5) triterpenoid isolated from Glochidion tomentosum, exhibited exceptional gelation ability compared to the screened lupane- and oleanane-type triterpenoids. This study represents the first report on the self-assembly behavior of glochidonol in various liquids. The molecule self-assembled to form gels in all tested aromatic solvents, whereas no gelation was observed in water or phosphate buffer. The structural and physical properties of the self-assembled glochidonol were characterized using optical microscopy, scanning electron microscopy, atomic force microscopy, and Fourier-transform infrared spectroscopy. Additionally, the glochidonol-based self-assembled fibrillar network was utilized for the encapsulation of fluorescein isothiocyanate as a model drug, highlighting its potential for biomedical applications. A glochidonol-based gel loaded with doxorubicin exhibited sustained, diffusion-mediated drug release into PBS, accompanied by partial gel degradation. Fluorescence analysis confirmed release suggesting drug-gel interactions and diffusion. The glochidonol-based gel demonstrated sustained, diffusion-controlled doxorubicin release with partial degradation under physiological conditions.</p>
},
	keywords = {Glochidion tomentosum, Glochidonol, Organo gelator, Self-assembly, Triterpenoids},
	issn = {2365-6549},
	doi = {10.1002/slct.202501207},
	author = {Patil, Harshal S. and Jagadeesh, K. S. and Dinore, Jaysingh and Sharanappa, P. and Baviskar, Ashwini S. and Thulasiram, Hirekodathakallu V.}
}
