@article {49836,
	title = {Synthesis of benzannulated [5,6] oxa-fused/spiro-lactones via [4+2] cycloaddition with quinone methides: new insights into deconjugated butenolide reactivity},
	journal = {Journal of Organic Chemistry},
	volume = {90},
	year = {2025},
	month = {OCT},
	pages = {15185-15190},
	type = {Article},
	abstract = {<p>
	In this study, we unfold a Lewis-acid-catalyzed inverse electron demand hetero Diels-Alder (IEDHDA) [4 + 2] reaction, leveraging the unique beta-selective nucleophilicity of deconjugate lactone in conjunction with quinone methides for the synthesis of polycyclic fused and spiro acetals in a one-pot process. This cascade annulation reaction efficiently generates 3/4 chiral centers with high diastereoselectivity. The developed methodology proceeds under mild reaction conditions and exhibits a broad substrate scope for fused and spiro acetal formation.</p>
},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.5c01468},
	author = {Kumar, Manish and Kale, Someshwar B. and Jawahar, Subramani and Barkade, Apurva D. and Das, Utpal}
}
