@article { ISI:000348245000002,
	title = {Comprehensive study on the effect of acid additives in 1(R),2(R)-Bis[(S)-prolinamido]cyclohexane catalyzed direct asymmetric aldol reactions in aqueous media},
	journal = {Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry},
	volume = {54},
	number = {1},
	year = {2015},
	month = {JAN},
	pages = {84-92},
	publisher = {COUNCIL SCIENTIFIC \& INDUSTRIAL RES},
	address = {ANUSANDHAN BHAWAN, 2 RAFI MARG, NEW DELHI, 110001, INDIA},
	abstract = {<p>The catalytic efficacy of (1R,2R)-bis[(S)-prolinamido]cyclohexane 1, prepared from the readily available natural amino acid L-proline has been studied for the direct asymmetric aldol reaction of cyclohexanone with substituted benzaldehydes at room temperature in presence of various acid additives. A wide variety of acids e.g. aliphatic fatty acid, chiral acid, sulphonic acid, aromatic acid, etc. have been used as additive for the aldol reaction in aqueous media. A loading of 10 mol\% of catalyst 1 is employed in this reaction, and good yields (up to 98\% yield), diastereoselectivity (up to 96\% de) and enantioselectivities (up to 87\% ee) can be achieved in aqueous media within very short reaction time (1-4 hours).</p>},
	keywords = {acid additives, aqueous media, Asymmetric synthesis, direct aldol reaction, organocatalysis},
	issn = {0376-4699},
	author = {Bhowmick, Sudipto and Kunte, Sunita S. and Bhowmick, Kartick C.}
}
