@article {49622,
	title = {Phosphite mediated molecular editing via switch to meta-C-H alkylation of isoquinolines: emergence of a distinct photochemical [1,3] N to C rearrangement},
	journal = {Chemical Science},
	volume = {16},
	year = {2025},
	month = {JAN},
	pages = {1809-1818},
	type = {Article},
	abstract = {<p>
	The isoquinoline core is present in one of the largest subsets of bioactive natural products. The multifunctional isoquinoline core exerts diverse bioactivity, resulting in the development of numerous isoquinoline-based drugs and molecules that are currently under clinical trials. We developed a new approach for phosphite-mediated [1,2] alkyl migration for an overall ortho-C-H alkylation via N-alkylation of isoquinoline. Tuning the phosphite-mediated protocol to switch the site selectivity would expedite direct and diverse multi-C-H bond functionalization. We report a new approach starting with a simple N-alkylation of isoquinoline with sterically and electronically diverse alkyl bromides for their phosphite-mediated photochemical [1,3] N to C rearrangement followed by a rearomatization sequence that leads to meta-C-H (C4) alkylation. Combined experimental and computational studies unveiled the emergence of an unprecedented C-N bond cleavage pathway from the singlet excited state of the enamine-type intermediate. Our radical bond-cleavage pathway favors substituted alkyl group migration that complements the recently successful meta-alkylation methods with smaller and more reactive electrophiles. This switch in site selectivity via tuning the phosphite-mediated protocol resulted in sequential C-H difunctionalization of isoquinoline including regiodivergent ortho, meta-dialkylations of isoquinolines.</p>
},
	issn = {2041-6520},
	doi = {10.1039/d4sc07127a},
	author = {Rani, Soniya and Ray, Anuj Kumar and Dewangan, Devendra Kumar and Patil, Nita Aruna Ramchandra and Aarthika, M. and Paul, Ankan and Maity, Pradip}
}
@article {49775,
	title = {Unified photoredox-catalyzed aerobic oxidative dynamic kinetic asymmetric transformation for C-N atropoisomers mediated by chiral organophosphites},
	journal = {Organic Letters},
	volume = {27},
	year = {2025},
	month = {AUG },
	pages = {8171-8177},
	type = {Article},
	abstract = {<p>
	The synthesis of anilides with a chiral C(=O)-N axis has relied on direct installation of the chiral C(sp2)-N(sp2) bond or enantioselective modification of the peripheral groups. However, these methods are constrained by the size and type of functional groups compatible with each strategy. Herein, we report a dynamic kinetic asymmetric transformation (DYKAT) for the aerobic oxidation of iminium ions to access C(=O)-N axial chirality that addresses those limitations. Furthermore, it eliminates the need for any auxiliary functional groups, which enables us to develop a unified method for the synthesis of atroposelective isoquinolone, lactam, and amide.</p>
},
	issn = {1523-7060},
	doi = {10.1021/acs.orglett.5c02273},
	author = {Saikia, Pinku and Aarthika, M. and Bhattacharjya, Ayantika and Maity, Susmita and Bajpai, Priyam and Bera, Asish and Saha, Arindam and Gonnade, Rajesh G. and Vanka, Kumar and Maity, Pradip}
}
