@article {42691, title = {Synthesis of azobenzenophanes with a large molecular cavity}, journal = {Australian Journal of Chemistry}, volume = {59}, year = {2006}, month = {JAN}, pages = {75-77}, type = {Article}, abstract = {

The design and synthesis of four large-cavity azobenzenophanes, capable of forming photochemically controllable complexes with organic guest molecules, are described. These azobenzenophanes, possessing m-terphenyl, aromatic carbonyl, and chiral BINOL spacers, were synthesized from the corresponding bisphenols and dibromides using simple O-alkylation methodology. A preliminary photochemical study was carried out on the aromatic carbonyl spacer containing azobenzenophane, and the isosbestic points for the cis{\textendash}trans isomerization process appeared at 319 and 419 nm.

}, doi = {10.1071/CH05254}, author = {Rajakumar, Perumal and Senthilkumar, B. and Srinivasan, Kannupal} } @article {42690, title = {One-pot process for the conversion of aroyl chlorides to acyl thioureas}, number = {US 14/650,778}, year = {2013}, month = {JUL}, type = {Application}, chapter = {PCT/IN2013/000758}, abstract = {

The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80\%, from aroyl chlorides of formula (I) wherein, R' is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R" and R'" are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

}, author = {Ramana, Chepuri V. and Senthilkumar, B.} } @article { ISI:000349669300018, title = {Pd-catalyzed benzylic C-H oxidation of cyclotriveratrylene - product diversity}, journal = {Organic \& Biomolecular Chemistry}, volume = {13}, number = {8}, year = {2015}, month = {DEC}, pages = {2323-2329}, publisher = {ROYAL SOC CHEMISTRY}, address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND}, abstract = {

The inner-rim functionalization of CTV has been examined by employing Pd-catalyzed benzylic oxidation. The outcome of the oxidation depends upon the solvent and co-oxidants employed. An interesting array of CTV derivatives has been synthesized with a simple change in the conditions.

}, issn = {1477-0520}, doi = {10.1039/c4ob02469a}, author = {Senthilkumar, B. and Gonnade, Rajesh G. and Ramana, C. V.} } @article {48205, title = {BQ-AurIPr: a redox-active anticancer Au(i) complex that induces immunogenic cell death}, journal = {Chemical Science}, volume = {13}, year = {2022}, month = {SEP}, pages = {10779-10785}, type = {Article}, abstract = {

Immunogenic Cell Death (ICD) is a unique cell death mechanism that kills cancer cells while rejuvenating the anticancer immunosurveillance, thereby benefiting the clinical outcomes of various immuno-chemotherapeutic regimens. Herein, we report development of a library of benzo[a]quinolizinium-based Au(i) complexes through an intramolecular amino-auration reaction of pyridino-alkynes. We tested 40 candidates and successfully identified BQ-AurIPr as a novel redox-active Au(i) complex with potent anticancer properties. BQ-AurIPr efficiently triggered generation of DAMPs - the hallmarks of ICD - and was superior in terms of efficiency compared to FDA-approved drugs known to induce ICD. BQ-AurIPr significantly increased immunogenicity of cancer cells enhancing their phagocytosis when co-cultured with immune cells. Our investigation reveals that BQ-AurIPr induces oxidative stress inside mitochondria leading to mitophagy, as the mechanism for immunogenic cell death in A549 cells.

}, issn = {2041-6520}, doi = {10.1039/d2sc03756d}, author = {Mule, Ravindra D. and Kumar, Akhilesh and Sancheti, Shashank P. and Senthilkumar, B. and Kumar, Himanshu and Patil, Nitin T.} }