@article {49799,
	title = {Diastereoselective synthesis of cyclic and spirocyclic quaternary carbons via iron-catalyzed ring contraction of cyclic ketones: a formal synthesis of perhydrohistrionicotoxin},
	journal = {Organic Letters},
	volume = {27},
	year = {2025},
	month = {AUG },
	pages = {8798-8803},
	type = {Article},
	abstract = {<p>
	The iron-catalyzed hydrogen atom transfer (HAT)-initiated Dowd-Beckwith rearrangement presents a new approach for synthesizing cyclic and spirocyclic quaternary carbons from readily available beta-keto esters and cyclic diketones with high yields. This reaction proceeds in a stereocontrolled manner, enabling the formation of synthetically valuable cyclic ketones with two contiguous stereocenters, including quaternary centers. This transformation introduces an innovative bond disconnection strategy for ring-contraction reactions. Additionally, a short formal synthesis of perhydrohistrionicotoxin was efficiently achieved using this methodology.</p>
},
	issn = {1523-7060},
	doi = {10.1021/acs.orglett.5c02888},
	author = {Survase, Vijayanand U. and Rokade, Avinash D. and Handore, Kishor L.}
}
@article {49509,
	title = {Stereoselective strategies for the synthesis of functionalized cis-hydrindanes in natural product synthesis},
	journal = {European Journal of Organic Chemistry},
	volume = {28},
	year = {2025},
	month = {APR},
	type = {Review},
	abstract = {<p>
	The cis-hydrindane motif is a bicyclic structure commonly found in many natural products that exhibit significant biological activity. This structural feature is present in a variety of bioactive compounds, particularly terpenoids, steroids, and alkaloids, which are known for their therapeutic potential, including anti-inflammatory, antimicrobial, antiviral, and anticancer properties. Due to its prevalence and biological relevance, the cis-hydrindane framework has attracted considerable attention from synthetic chemists, who have devoted substantial effort toward developing efficient and diverse methods for constructing this important motif. Many of the synthesized cis-hydrindane compounds have been used as key intermediates or building blocks in the total synthesis of complex natural products. This review provides an overview of strategic approaches for synthesizing functionalized cis-hydrindanes and its derivatives from 2000 to the present day, focusing on their application in natural product synthesis. By examining the diverse methods and their impact on natural product synthesis, this review will underscore the enduring importance of the cis-hydrindane framework in both synthetic organic chemistry and medicinal chemistry.</p>
},
	keywords = {annulation, Cis-hydrindane, Diel-Alder reaction, Natural products, Total synthesis},
	issn = {1434-193X},
	doi = {10.1002/ejoc.202500006},
	author = {Survase, Vijayanand U. and Handore, Kishor L.}
}
