@article {49561,
	title = {Divergent access to α-carbonyl-α'-vinyl sulfoxonium ylides and polysubstituted furans from β-ketosulfoxonium ylides and ynone-esters},
	journal = {Journal of Organic Chemistry},
	volume = {90},
	year = {2025},
	month = {APR},
	pages = {6186-6207},
	type = {Article},
	abstract = {<p>
	Here, we describe the synthesis of novel alpha-carbonyl-alpha {\textquoteleft}-vinyl sulfoxonium ylides under ambient, catalyst-free, and additive-free conditions, demonstrating broad substrate scope and scalability using beta-ketosulfoxonium ylides and alpha-ynone-esters. Furthermore, these ylides serve as versatile intermediates for the synthesis of highly substituted furans via Br \&amp; oslash;nsted acid (p-TsOH) catalysis at 130 degrees C. This approach offers key advantages, including wide substrate compatibility, divergent product formation from common precursors, gram-scale feasibility, and good to excellent yields.</p>
},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.5c00245},
	author = {Ingale, Sudhir R. and Sahu, Manas Ranjan and Borade, Balasaheb R. and Gamidi, Rama Krishna and Kontham, Ravindar}
}
@article {49500,
	title = {Total synthesis of linear lipodepsipeptide kavaratamide A and its C25-epimer},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {23},
	year = {2025},
	month = {FEB},
	pages = {1819-1822},
	type = {Article},
	abstract = {<p>
	We report the stereoselective total synthesis of kavaratamide A, a linear lipodepsipeptide from the cyanobacterium Moorena bouillonii (collected in Kavaratti, India), and its unnatural C25-epimer. The convergent approach employs Keck asymmetric allylation to construct the chiral beta-hydroxy carboxylic acid fragment [(3S)-HDA; 3-hydroxydecanoic acid], while the peptide unit was assembled from l-Val, N-Me-l-Ala, (S)-Hiva, and (S)-iPr-O-Me-pyr using well-orchestrated coupling methods to prevent racemization. Modifications to the Keck allylation conditions enabled the synthesis of the C25-epimer with good yield. Cytotoxicity of kavaratamide A and C25-epi-kavaratamide A, assessed using the MTT assay, demonstrated moderate activity against HepG2 and PANC-1 cell lines.</p>
},
	issn = {1477-0520},
	doi = {10.1039/d4ob01970a},
	author = {Sahu, Manas Ranjan and Ingale, Sudhir R. and Kontham, Ravindar}
}
