@article {49341, title = {Cu-catalyzed multicomponent reaction of arylhydrazines with β-ketoesters and TBN: one-pot access to N 2-aryl 1,2,3-triazole-1-oxides}, journal = {Journal of Organic Chemistry}, volume = {89}, year = {2024}, month = {NOV }, pages = {16990-16998}, type = {Article}, abstract = {

We report a copper-catalyzed one-pot, multicomponent strategy for the convenient synthesis of N 2-aryl 1,2,3-triazole-1-oxides using arylhydrazines, beta-ketoesters, and tert-butyl nitrite. This mild and simple reaction proceeds in an atom-economic manner with broad substrate scope, affording a variety of N 2-aryl 1,2,3-triazole-1-oxide derivatives. Other salient features of the reaction are good functional group tolerance, scalability, and product diversification.

}, issn = {0022-3263}, doi = {10.1021/acs.joc.4c00298}, author = {Mujahid, Mohammad and Vara, Vijay and Arshad, Usman and Gamidi, Rama Krishna and Muthukrishnan, M.} } @article {49851, title = {Ag(I)-catalyzed heterocyclization/[3+2] cycloaddition of α-alkynylenones with β-enaminones: tandem access to highly substituted cyclopenta[c]furans}, journal = {Journal of Organic Chemistry}, volume = {90}, year = {2025}, month = {SEP }, pages = {12466-12479}, type = {Article}, abstract = {

A robust Ag(I)-catalyzed tandem heterocyclization/[3 + 2] cycloaddition of alpha-alkynylenones with beta-enaminones was developed, enabling efficient synthesis of cyclopenta[c]furans with good yields, operational simplicity, and broad substrate scope. In addition, it also presents an extended methodology to synthesize unsymmetrical tri(hetero)aryl methane having chromone and furan/pyrrole scaffolds by a slight modification of starting materials. Moreover, the synthesized cyclopenta[c]furans exhibit good fluorescence properties with quantum yields ranging from 0.33 to 0.53, as suggested by the photophysical studies.

}, issn = {0022-3263}, doi = {10.1021/acs.joc.5c01707}, author = {Vara, Vijay and Thete, Kishor R. and Panikar, Sera Deepu and Khan, Akram A. and Muthukrishnan, M.} } @article {49881, title = {Efficient Copper-Catalyzed, One-Pot Synthesis of N2-Aryl Phosphoryl 1,2,3-Triazole 1-Oxides}, journal = {Asian Journal of Organic Chemistry}, volume = {14}, year = {2025}, month = {OCT}, pages = {e00162}, type = {Article}, abstract = {

A simple and facile one-pot process has been developed for the synthesis of N 2-aryl phosphoryl 1,2,3-triazole 1-oxide derivatives. This new approach utilizes simple and commercially available starting materials, operating under mild conditions. The method employs copper-catalyzed multicomponent reaction, involving the combination of arylhydrazines, beta-ketophosphonates, and tert-butyl nitrite. The developed protocol shows excellent functional group tolerance permitting an extensive range of substrate scope up to 92\% isolated yield.

}, keywords = {Copper-catalyzed, Phosphoryl triazoles N-oxides, Phosphorylated compound, Triazole N-oxides}, issn = {2193-5807}, doi = {10.1002/ajoc.202500162}, author = {Mujahid, M. and Bhavar, Akshay A. and Vara, Vijay and Gonnade, Rajesh and Muthukrishnan, M.} } @article {49399, title = {Manganese-mediated cascade radical oxidative cyclization/1,6-conjugate addition of unsaturated oximes with p-quinone methides: facile access to β,β-diarylmethine substituted isoxazolines}, journal = {Chemistry-An Asian Journal}, volume = {20}, year = {2025}, month = {JAN}, type = {Article}, abstract = {

A simple and efficient strategy for the synthesis of structurally diverse beta,beta-diarylmethine substituted isoxazoline derivatives have been developed. This approach employs a manganese-promoted oxidative cyclization coupled with a 1,6-conjugate addition of unsaturated oximes to p-quinone methides. The key features of this study include the formation of C-O and C-C bonds through intramolecular and intermolecular interactions, facilitated by in situ generated iminoxyl radicals. beta,beta-diarylmethine substituted isoxazolines, bearing a wide range of functional groups, were isolated in high yields.

}, keywords = {p-Quinone methide, diarylmethine substituted isoxazolines, Iminoxy radical, Manganese catalyzed}, issn = {1861-4728}, doi = {10.1002/asia.202401079}, author = {Vara, Vijay and Thete, Kishor R. and Ghotekar, Ganesh S. and Muthukrishnan, M.} } @article {49790, title = {Phosphine-catalyzed nucleophilic ring opening of cyclopropenones with sulfoximines to access N-α,β-unsaturated acyl sulfoximines}, journal = {Journal of Organic Chemistry}, volume = {90}, year = {2025}, month = {AUG}, pages = {10643-10653}, type = {Article}, abstract = {

Herein, we describe the formation of biologically relevant N-alpha,beta-unsaturated acyl sulfoximines via phosphine-catalyzed C-C bond activation of cyclopropenones with weakly nucleophilic sulfoximines. The new process does not require a transition metal or external oxidant and displays high regioselectivity and exclusive E-selectivity. Other salient features of the method are a broad substrate scope, high compatibility with various functional groups, and high atom economy.

}, issn = {0022-3263}, doi = {10.1021/acs.joc.5c00883}, author = {Thete, Kishor R. and Vara, Vijay and Khan, Akram A. and Muthukrishnan, M.} } @article {50022, title = {Radical-promoted cyclization of 3-allyl-2-arylquinazolinones mediated by silver(i) salts to access SCF3/SCN-enriched dihydroisoquinolino[1,2-b]quinazolinones}, journal = {Organic \& Biomolecular Chemistry}, volume = {24}, year = {2026}, month = {FEB}, pages = {1263-1267}, type = {Article}, abstract = {

Herein, we describe an efficient approach for the synthesis of SCF3- and SCN-functionalized polycyclic dihydroisoquinolino[1,2-b]quinazolinones through radical-mediated thio-functionalization of allylic alkenes followed by intramolecular cyclization. The transformation proceeds through sulfur-radical-triggered C-S and C-C bond formation, providing an efficient route to sulfur- and fluorine-enriched polycyclic quinazolinones. Moreover, this strategy offers high atom economy, operational simplicity, and broad substrate compatibility.

}, issn = {1477-0520}, doi = {10.1039/d5ob01755f}, author = {Vara, Vijay and Thete, Kishor R. and Khan, Akram A. and Muthukrishnan, M.} }