@article {49257,
	title = {Biocatalysis enables the scalable conversion of biobased furans into various furfurylamines},
	journal = {NATURE COMMUNICATIONS},
	volume = {15},
	year = {2024},
	month = {JUL },
	type = {Journal Article},
	keywords = {Biomass, OMEGA-TRANSAMINASE, OXIDASE, Reductive amination, SPECIFICITY},
	doi = {10.1038/s41467-024-50637-x},
	author = {Giri, Pritam and Lim, Seonga and Khobragade, Taresh P. and Pagar, Amol D. and Patil, Mahesh D. and Sarak, Sharad and Jeon, Hyunwoo and Joo, Sangwoo and Goh, Younghwan and Jung, Seohee and Jang, Yu-Jeong and Choi, Seung Beom and Kim, Ye Chan and Kang, Taek Jin and Heo, Yong-Seok and Yun, Hyungdon}
}
@article {49968,
	title = {Total biocatalytic synthesis of capsaicinoids using ferulic acid: a versatile two-step strategy for natural product diversification},
	journal = {Angewandte Chemie-International Edition},
	volume = {64},
	year = {2025},
	month = {DEC },
	type = {Article},
	abstract = {<p>
	The wide-ranging application of capsaicinoids, the active compounds in chili peppers, has driven increasing interest in the development of sustainable production strategies. However, capsaicinoid synthesis remains a challenge. The objective of this pioneering study is to report the total biocatalytic synthesis of structurally diverse capsaicinoids from bio-based ferulic acids. An X-ray crystallographic study elucidated the structural basis for the exceptional potential of a novel transaminase from Phaeobacter porticola (PPTA) to transform the highest ever reported concentration of vanillin (100-200 mM) to vanillylamine, with \&gt;99\% conversion and modest conversion ranging from 48\% to 79\% for 300 to 500 mM substrate. Using PPTA in tandem with phenolic acid decarboxylase (PAD) and aromatic dioxygenase (ADO) further enabled the direct synthesis of vanillylamine from ferulic acid with \&gt;99\% conversion. Furthermore, the integration of a multi-enzymatic cascade with carboxylic acid reductases (CARs) successfully synthesized structurally diverse capsaicinoids via amide bond formation between vanillylamine and free fatty acids, with excellent conversions ranging from 72\% to \&gt;88\%. A 50-mM enzymatic reaction afforded 95\% and 80\% conversion of vanillylamine and capsaicin, respectively.</p>
},
	keywords = {Capsaicinoids, Carboxylic acid reductase, Transaminase, Vanillylamine},
	issn = {1433-7851},
	doi = {10.1002/anie.202514504},
	author = {Khobragade, Taresh P. and Giri, Pritam and Patil, Mahesh D. and Joo, Sangwoo and Cho, Sunga and Kim, Yechan and Ghosh, Rohan and Jeong, Sanghun and Maeng, Minyeong and Song, Min-Ho and Park, Jeong-Min and Lee, Eun Ho and Keum, Young-Soo and Kang, Taek Jin and Heo, Yong-Seok and Yun, Hyungdon}
}
