@article {49126,
	title = {Chloroperoxidase applications in chemical synthesis of industrial relevance},
	journal = {Biocatalysis and Biotransformation},
	volume = {41},
	year = {2023},
	month = {NOV },
	pages = {403-420},
	type = {Article},
	abstract = {<p>
	Biocatalysts can accelerate the catalysis of a chemical reaction that is difficult to synthesize with typical chemical methods. The global enzyme market size is predicted to expand at a CAGR of 6.5\% from 2021 to 2028. Enzymatic reactions are highly chemo, regio, and stereoselective and produce various fine chemicals such as drugs, agrochemicals, and fragrance molecules. Peroxidases (PO) (EC 1.11.1.x) are a large class of enzymes that play an important role in various biological processes. Chloroperoxidase (CPO, EC 1.1.1.10) is a versatile fungal haem-thiolate protein that is useful in the asymmetric synthesis of chiral building blocks and has an important role in a number of biological processes. CPO{\textquoteright}s main biological role is chlorination, although it also catalyses haem PO, catalase (CAT), and reactions similar to cytochrome P450. However, CPO performs both oxidation and stereo-specific halogenation of chemical molecules. The haem and vanadium POs are produced by Caldariomyces fumago, and Curvularia inaequalis, respectively, and are capable of halogenating the flavanones, naringenin, and hesperetin, at C-6 and C-8 in the presence of either Cl- or Br-. In this review, we discussed the various applications of CPO including synthesis of epoxides, drugs, halogenation of thymol, nitriles, the Aza-Achmatowicz reaction, and biomedical applications such as cancer and biosensors. In light of these novel features, we have provided a detailed review of CPOs and their applications in various stereoselective chemical transformations of industrial relevance.</p>
},
	keywords = {active pharmaceutical ingredients, Biotransformation, Caldariomyces fumago, chemo, Chloroperoxidase, regio, stereoselectivity},
	issn = {1024-2422},
	doi = {10.1080/10242422.2022.2107919},
	author = {Bhandari, Yogesh and Sajwan, Hemlata and Pandita, Parul and Koteswara Rao, Vamkudoth}
}
