@article {49092,
	title = {Br{\o}nsted acid- and Ni(<sc>ii</sc>)-catalyzed C-H oxidation/rearrangement of cyclotriveratrylenes (CTVs) to cyclic and acyclic quinones as potential anti-cancer agents},
	journal = {Organic and biomolecular chemistry},
	volume = {22},
	year = {2024},
	month = {JAN },
	pages = {1038-1046},
	type = {Article},
	abstract = {<p>
	This paper describes a simple and practical protocol for the direct synthesis of acyclic and cyclic quinone derivatives via an acid-promoted nickel(ii)-catalyzed inner rim C-H oxidation of cyclotriveratrylene (CTV) and its analogues. The cyclic quinone derivatives resulted from trimethoxy-cyclotriveratrylene (TCTV) through C-C bond formation via intramolecular ipso substitution followed by subsequent anionic rearrangement containing stereo-vicinal quaternary centers. The DFT calculations strongly support the experimental findings and reveal the role of Bronsted acids in the C-H bond activation of CTV. All the newly synthesized compounds were screened for their in vitro anti-cancer activity using colorimetric SRB assay analysis. Among them, compounds 3a, 3d, 3h, 4a, 4b, 4c and 4e exhibited moderate anticancer activity against A549, HCT-116, PC-3, MDA-MB-231, HEK-293 and SW620 human cancer cell lines.</p>
},
	issn = {1477-0520},
	doi = {10.1039/d3ob01428b},
	author = {Darole, Ratanamala S. and Choudhary, Shailendra Singh and Sharma, Himanshu and Mali, Bhupendra P. and Gopu, Booblan and Vanka, Kumar and Senthilkumar, Beeran}
}
@article {49832,
	title = {Base mediated approach for the synthesis of deoxybenzoins using γ-aryl-β-ketoesters and benzoyl chlorides},
	journal = {RSC Advances},
	volume = {15},
	year = {2025},
	month = {SEP },
	pages = {32424-32430},
	type = {Article},
	abstract = {<p>
	This study introduces a one-pot, transition metal-free strategy for synthesizing deoxybenzoins, overcoming the challenges of conventional methods. The reaction involves dual acylation of gamma-aryl beta-keto esters using K2CO3 in dioxane at 90 degrees C, followed by a concerted transformation to form deoxybenzoin. The protocol operates under mild conditions, tolerates a broad range of substrates, and produces minimal by-products, making it a practical, scalable alternative for accessing pharmaceutically relevant deoxybenzoins.</p>
},
	doi = {10.1039/d5ra05242d},
	author = {Choudhary, Shailendra Singh and Darole, Ratanamala S. and Krishna, Gamidi Rama and Senthilkumar, Beeran}
}
