@article {49088,
	title = {Nonedible thevetia peruviana oil for the synthesis of biobased thermosets and vitrimers with tunable mechanical properties},
	journal = {ACS Applied Polymer Materials },
	volume = {6},
	year = {2024},
	month = {FEB },
	pages = {2695-2708},
	type = {Article},
	abstract = {<p>
	Current attempts to replace fossil-derived materials with vegetable oils for polymer production mainly rely on edible oils. This approach raises sustainability concerns due to potential food security risks. This report introduces the first in-depth examination of Thevetia peruviana oil (TPO) epoxidation, an easily accessible nonedible vegetable oil, utilizing diverse acidic ion-exchange resins as catalysts. It is followed by the development of vitrimers based on epoxidized oil (ETPO) with various dicarboxylic acid hardeners. Amberlite IRC120H emerged as the most effective catalyst for the epoxidation of the oil, allowing for repeated catalyst reusability for up to five cycles. An impressive relative oxirane conversion of 98.9\% was achieved after optimization. DSC analysis revealed that among the diacids, 2,2{\textquoteright}-dithiodibenzoic acid (DTBZ) has the lowest activation energy with ETPO. Additionally, the ETPO-DTBZ-based thermosets displayed exceptional solvent resistance and thermal stability, indicative of a high degree of cross-linked networks within the system. Mechanical analyses revealed that all aliphatic hardeners resulted in soft materials, while DTBZ resulted in thermosets with tensile stress and modulus of 15 and 843 MPa, respectively. Consequently, DTBZ-ETPO thermosets were successfully recycled, repaired, and reshaped with minimal changes in the mechanical properties. The shape memory of the thermosets was also established.</p>
},
	keywords = {biobasedvitrimers, environmental sustainability, epoxidizedThevetial peruviana oil, nonedible oil, Optimization, shape memory},
	issn = {2637-6105},
	doi = {10.1021/acsapm.3c02923},
	author = {Olosho, Adebayo Isaac and Alam, Md Shafi and Sukumaran Nair, Kiran and Ambade, Ashootosh V. and Adekola, Folahan Amoo}
}
@article {50024,
	title = {Green synthesis of PLGA and fabrication of topotecan and thymoquinone dual anticancer drug loaded PLGA nanoparticles: a controlled release study for cancer therapy},
	journal = {Journal of Macromolecular Science Part A-Pure and Applied Chemistry},
	volume = {63},
	year = {2026},
	month = {MAR},
	pages = {232-246},
	type = {Article},
	abstract = {<p>
	Cancer therapy is often hindered by poor solubility, low bioavailability, drug resistance, and tumor microenvironmental barriers associated with conventional chemotherapeutics. Polymeric nano-drug delivery systems offer a promising strategy to overcome these limitations, particularly for synergistic multi-drug delivery. In this study, a biodegradable and biocompatible PLGA copolymer (70:30, M-w approximate to 14,500) was synthesized by ring-opening polymerization using zinc proline complex as an initiator through a green route. The copolymer{\textquoteright}s potential for delivering topotecan (TPT), a water-soluble chemotherapeutic, thymoquinone (TQ), a poorly water-soluble chemotherapeutic, and their combination (TPT+TQ) for cancer treatment was investigated. These nanoparticles demonstrateda consistent particle size \&lt; 200 nm high encapsulation efficiency along with desirable controlled-release attributes. Moreover, they exhibited specific release characteristics and cytotoxic effects against HeLa cells, achieving an IC50 value of 20.88 M for the combination therapy (TPT+TQ). Additionally, cytocompatibility testing on L929 fibroblasts confirmed over 98\% cell viability for blank PLGA nanoparticles. Additionally, confocal imaging studies confirmed efficient cellular uptake and nuclear localization of the nanoparticles. Overall, the PLGA based dual drug loaded nanoparticles presents a promising approach for targeted, synergistic co-delivery, potentially improving efficacy and reducing toxicity in cancer therapy.</p>
},
	keywords = {Biodegradation, dual drug-loading, PLGA copolymer, thymoquinone, Topotecan},
	issn = {1060-1325},
	doi = {10.1080/10601325.2026.2618022},
	author = {Srilatha Cheekuramelli, Naga and Muhammed, Hasin N. and Garnaik, Baijayantimala and Sukumaran Nair, Kiran}
}
