@article {46436,
	title = {Formal synthesis of brivaracetam: a key to construct the pyrrolidone scaffold using Pd-catalyzed oxidative cyclization and ring-closing metathesis reaction},
	journal = {Tetrahedron Letters},
	volume = {60},
	year = {2019},
	month = {NOV},
	pages = {151249},
	type = {Article},
	abstract = {<p>A short and efficient synthetic approach for brivaracetam has been accomplished via two different routes which utilize Pd-catalyzed oxidative cyclization and ring-closing metathesis (RCM) as the key reaction. These two routes are novel, simple, scalable and rely on (E)-pent-2-en-1-ol and valeraldehyde as a commercially available starting material to yield brivaracetam with good overall yield. (C) 2019 Published by Elsevier Ltd.</p>
},
	keywords = {Antiepileptic drugs, Pd-catalyzed oxidative cyclization, pyrrolinone, Ring-closing metathesis reaction},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2019.151249},
	author = {Chavan, Subhash P. and Kawale, Sanket A. and Chavan, Prakash N.}
}
@article {47664,
	title = {Formal synthesis of (-)-quinagolide: diastereoselective ring expansion via a bicyclic aziridinium ion strategy to access the octahydrobenzo[g]quinoline architecture},
	journal = {Journal of Organic Chemistry},
	volume = {86},
	year = {2021},
	month = {JUL },
	pages = {9344-9352},
	type = {Article},
	abstract = {The diastereoselective formal synthesis of (-)-quinagolide, a D-2 receptor agonist, has been achieved. The synthesis started from L-pyroglutamic acid and relied on utilization of (a) a stereospecific catalytic hydrogenation and diastereoselective Horner-Emmons-Michael cascade to obtain functionalized prolinate, (b) a Lewis acid mediated Pummerer cyclization to construct a tricyclic fused ring system, and (c) a diastereoselective ring expansion via a bicyclic aziridinium intermediate to access the required 3-substituted piperidine scaffold.},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.1c00603},
	author = {Chavan, Subhash P. and Kawale, Sanket A. and Pisal, Mahesh M. and Kadam, Appasaheb L. and Gonnade, Rajesh G.}
}
