@article {48009,
	title = {cis-aziridine synthon based synthetic investigation for tamiflu employing horner-wadsworth-emmons reaction},
	journal = {European Journal of Organic Chemistry},
	volume = {2022},
	year = {2022},
	month = {JUL },
	pages = {e202200384},
	type = {Article},
	abstract = {<p>
	Synthetic investigations to achieve a novel intermediate of Tamiflu by using cis-aziridine as a chiral building block, which is readily synthesized from (D)-mannitol as a renewable starting material, has been presented. The present approach utilizes the intramolecular Horner-Wadsworth-Emmons reaction as the key step for the synthesis of Tamiflu. On the other hand, diene containing allylic aziridine framework is found to be inefficient to furnish the six-membered core skeleton of Tamiflu through ring-closing metathesis reaction.</p>
},
	keywords = {Aziridine, cyclization, HWE reaction, Metathesis, Tamiflu},
	issn = {1434-193X},
	doi = {10.1002/ejoc.202200384},
	author = {Chavan, Subhash P. and Kawale, Sanket A. and Gonnade, Rajesh G.}
}
