@article { ISI:000345902500007,
	title = {Facile and convenient synthesis of (+/-)-Biotin via MgCl2/Et3N-mediated C-C coupling and mitsunobu reaction},
	journal = {Synlett},
	volume = {25},
	number = {20},
	year = {2014},
	month = {DEC},
	pages = {2879-2882},
	publisher = {GEORG THIEME VERLAG KG},
	type = {Article},
	address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY},
	abstract = {<p>A synthesis of (+/-)-biotin is described starting from simple starting materials viz. cyclohexanone and amino malonic acid ester. The key steps involved are MgCl2/Et3N coupling of amino malonic acid ester derivative and acid chloride, Mitsunobu reaction, ozonolysis, Staudinger reduction, novel urea formation, and subsequent dibenzylation. This approach is economical and involves high-yielding steps and simple reaction conditions.</p>},
	keywords = {Appel reaction, biotin, Mitsunobu reaction, Ozonolysis, Staudinger reduction},
	issn = {0936-5214},
	doi = {10.1055/s-0034-1379365},
	author = {Chavan, Subhash P. and Chavan, Prakash N. and Lasonkar, Pradeep B. and Khairnar, Lalit B. and Kadam, Appasaheb L.}
}
@article {46436,
	title = {Formal synthesis of brivaracetam: a key to construct the pyrrolidone scaffold using Pd-catalyzed oxidative cyclization and ring-closing metathesis reaction},
	journal = {Tetrahedron Letters},
	volume = {60},
	year = {2019},
	month = {NOV},
	pages = {151249},
	type = {Article},
	abstract = {<p>A short and efficient synthetic approach for brivaracetam has been accomplished via two different routes which utilize Pd-catalyzed oxidative cyclization and ring-closing metathesis (RCM) as the key reaction. These two routes are novel, simple, scalable and rely on (E)-pent-2-en-1-ol and valeraldehyde as a commercially available starting material to yield brivaracetam with good overall yield. (C) 2019 Published by Elsevier Ltd.</p>
},
	keywords = {Antiepileptic drugs, Pd-catalyzed oxidative cyclization, pyrrolinone, Ring-closing metathesis reaction},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2019.151249},
	author = {Chavan, Subhash P. and Kawale, Sanket A. and Chavan, Prakash N.}
}
