@article {49000,
	title = {Shape-controlled MoO3/MnO x nanocatalyst for the selective synthesis of 2-phenylquinoxaline drug motifs},
	journal = {ACS Applied Nano Materials},
	volume = {6},
	year = {2023},
	month = {DEC },
	pages = {23442-23453},
	type = {Article},
	abstract = {<p>
	We have developed a highly effective shape-controlled MoO3/MnOx nanocatalyst for the selective synthesis of 2-phenylquinoxaline drug motifs at room temperature without any external oxidant. Electron microscopy images reveal that the MnOx material contains rod-shaped particles (length: 500-1000 nm and width: 150-200 nm) and the MoO3 species are uniformly dispersed in the MoO3/MnOx material. The MoO3/MnOx nanocatalyst calcined at 500 degrees C (MoO3/MnOx-5) contains abundant strong acid sites and an optimum ratio of Mn4+/Mn3+, which are responsible for the C-N cross-coupling reaction between 2-phenylethylamine and o-phenylenediamine, giving higher yields (\&gt;96\%) of 2-phenylquinoxaline at mild conditions. The broad scope of this catalytic strategy at room temperature and without an external oxidant was confirmed by achieving \&gt;90\% yields of functional 2-phenylquinoxalines from C-N cross-coupling of various o-phenylenediamines and 2-phenylethylamines. The outstanding reusability efficiency of the MoO3/MnOx-5 nanocatalyst up to five cycles without the need for a regeneration step as well as the effective scalability highlighted the practicability of the MoO3/MnOx-based catalytic protocol for carbon-heteroatom coupling reactions at room temperature and without an external oxidant. Using computational studies, the possible reasons for the selective synthesis of 2-phenylquinoxaline over the MoO3/MnOx-5 nanocatalyst were elucidated.</p>
},
	keywords = {cascade C-N cross-coupling, DFT studies, room temperature andopen air, shape-controlled MoO3/MnOx nanocatalyst, structure-activity correlation},
	doi = {10.1021/acsanm.3c04820},
	author = {Singh, Nittan and Putla, Suresh Babu and Pratap Singh, Chandrodai and Kalbande, Pavan Narayan and Choudhary, Priyanka and Krishnamurty, Sailaja and Krishnan, Venkata and Bhatte, Kushal and Sudarsanam, Putla}
}
