@article {47622,
	title = {Manipulating hydrophobicity of polyester nanofiber mats with egg albumin to enhance cell interactions},
	journal = {Polymer Engineering and Science},
	volume = {61},
	year = {2021},
	month = {OCT},
	pages = {2496-2510},
	type = {Article},
	abstract = {A hybrid of poly-l-lactic acid (PLA) and poly-epsilon-caprolactone (PCL) system was designed using hydrophilic generally regarded as safe (GRAS) protein, egg albumin (EA), and fabricated as nanofiber mats (NM) to facilitate improved cell interactions and functionality. Our studies include, preparation and analysis of physicochemical properties of NM. Surface morphology of NM was smooth with the diameter ranging from 250 to 400 nm. The contact angle of NM decreased from 80 to 45 degrees with the increase in EA concentration. The rate and extent of swelling was increased 3-folds with the addition of EA. Release studies of NM showed maximum amount of MTz was released with the increase in MTz concentration (>85\%). The MTz interaction with EA and structure stability of EA was confirmed from fluorescence and circular dichroism studies. NM showed increase in inhibition of bacterial growth of Staphylococcus aureus and Escherichia coli with the increase in MTz concentration. Cell viability of the NM was >80\% and also, the cell proliferation increased as EA content increased. NM hemolytic activity was less than 5\% suggesting compatibility. Hence, results concluded that EA had regulated hydrophobicity, promoted cell interactions, and proliferation and therefore, NM is considered safe for tissue regeneration.},
	keywords = {Biocompatibility, Biomaterials, drug delivery systems, egg albumin, electrospinning, nanofibers, polyesters},
	issn = {0032-3888},
	doi = {10.1002/pen.25776},
	author = {Patel, Pratikshkumar R. and Pandey, Komal and Killi, Naresh and Gundloori, Rathna Venkata Naga}
}
@article {47995,
	title = {Blend of neem oil based polyesteramide as magnetic nanofiber mat for efficient cancer therapy},
	journal = {Journal of Drug Delivery Science and Technology},
	volume = {75},
	year = {2022},
	month = {SEP},
	pages = {103629},
	type = {Article},
	abstract = {<p>
	Stearic acid-coated magnetic nanoparticles (SMN) and FU (5-Fluorouracil) were immobilized in the blends of neem oil-based polyesteramide and fabricated as nanofiber mat (NM) for controlled release of FU under the influence of an external magnetic field for targeted drug delivery to treat cancer efficiently. Analyzed the surface morphology of the fibers using E-SEM, it was observed that the fibers were smooth with the diameter ranging from 250 to 450 nm. TEM studies showed the uniform distribution of SMN in the nanofibers. The physico-chemical properties of NM and raw materials were analyzed using FTIR, TGA, and XRD. The results suggested that the polymers were well blended. In-vitro FU release studies of the NMs recorded a significant difference in the cumulative percentage of FU release from SMN-NMs. The SMN-NMs released 95\% of FU in 4 h, whereas, NMs released 83\% of FU in 24 h. The cell viability assay for the NM was evaluated in the L929 mouse fibroblast cells, where \&gt;75\% of cells were viable. The hemolysis assay for the developed SMN-NF showed \&lt;5\% of hemolysis, which indicated the NMs were safe for application. The anti-cancer activity of FU loaded SMN-NF was analyzed in the MCF-7 cancer cell line, which recorded more than 50\% cell death within 24 h. From SQUID analysis, we found that the 10\% SMN were superparamagnetic in nature, the magnetization at 30 kOe was observed to be 4.3 emu/g. Based on the in vitro results, we concluded that the developed SMN-NMs are recommended for in vivo studies to understand their efficacy for the targeted drug delivery to treat cancer.</p>
},
	keywords = {5-Fluorouracil, drug release, electrospinning, Magnetic nanoparticles, nanofibers, Stearic acid},
	issn = {1773-2247},
	doi = {10.1016/j.jddst.2022.103629},
	author = {Patel, Pratikshkumar R. and Singam, Amarnath and Dadwal, Arun and Gundloori, Rathna Venkata Naga}
}
@article {48438,
	title = {Review on electrospun nanofibers for multiple biomedical applications},
	journal = {Polymers for Advanced Technologies},
	volume = {34},
	year = {2023},
	month = {JAN},
	pages = {44-63},
	type = {Review},
	abstract = {<p>
	Electrospinning is a well-known technique since 1544 to fabricate nanofibers using different materials like polymers, metals oxides, proteins, and many more. In recent years, electrospinning has become the most popular technique for manufacturing nanofibers due to its ease of use and economic viability. Nanofibers have remarkable properties like high surface-to-volume ratio, variable pore size distribution (10-100 nm), high porosity, low density, and are suitable for surface functionalization. Therefore, electrospun nanofibers have been utilized for numerous applications in the pharmaceutical and biomedical field like tissue engineering, scaffolds, grafts, drug delivery, and so on. In this review article, we will be focusing on the versatility, current scenario, and future endeavors of electrospun nanofibers for various biomedical applications. This review discusses the properties of nanofibers, the background of the electrospinning technique, and its emergence in chronological order. It also covers the various types of electrospinning methods and their mechanism, further elaborating the factors affecting the properties of nanofibers, and applications in tissue engineering, drug delivery, nanofibers as biosensor, skin cancer treatment, and magnetic nanofibers.</p>
},
	keywords = {biomaterial, drug delivery, electrospinning, Nanofiber, tissue engineering},
	issn = {1042-7147},
	doi = {10.1002/pat.5896},
	author = {Patel, Pratikshkumar R. and Gundloori, Rathna Venkata Naga}
}
