@article {43903, title = {Polyhydroxyalkanoates as biomaterials}, journal = {MedChemComm}, volume = {8}, year = {2017}, month = {SEP}, chapter = {1774-1787}, abstract = {

Polyhydroxyalkanoates (PHAs) are biopolymers synthesized by bacteria under unbalanced growth conditions. These biopolymers are considered as potential biomaterials for future applications because they are biocompatible, biodegradable, and easy to produce and functionalize with strong mechanical strength. Currently, PHAs are being extensively innovated for biomedical applications due to their prerequisite properties. The wide range of biomedical applications includes drug delivery systems, implants, tissue engineering, scaffolds, artificial organ constructs, etc. In this article we review the utility of PHAs in various forms (bulk/nano) for biomedical applications so as to bring about the future vision for PHAs as biomaterials for the advancement of research and technology.

}, keywords = {Biomedical Applications, Cancer-therapy, Drug-delivery Systems, In-vitro, Molecular-weight, Poly(Ester Urethane)S, poly(ethylene glycol), Regenerative Medicine, Tissue Engineering Applications, Vitro Antibiotic Release}, issn = {2040-2503}, doi = {10.1039/c7md00252a}, author = {Bhagyashri, S. and Gadgil, Thorat and Killi, Naresh and Rathna, Gundloori V. N.} } @article {47172, title = {Polyesteramide of neem oil and its blends as an active nanomaterial for tissue regeneration}, journal = {ACS Applied Bio Materials}, volume = {2}, year = {2019}, month = {JUL}, pages = {3341{\textendash}3351}, type = {Article}, abstract = {

Neem oil gained importance due to its antibacterial properties. Therefore, it is extensively being used for various applications. Oils can be polymerized as a polyesteramide to extend their utility as biomaterials. In our studies, we synthesized polyesteramide from neem oil and various compositions of blends were prepared with the drug, chlorohexidine digluconate (CH) to develop a nanomaterial for tissue regeneration. The studies such as cytotoxicity, biodegradable, antibacterial, in vitro drug release, in vivo wound healing, and histopathological studies were performed to identify their potential for tissue regeneration. In vivo wound healing studies of the nanofiber mats with and without CH recorded a faster healing rate as compared to the commercial cream (povidone{\textendash}iodine). Most importantly, there was no requirement of repeated application of nanofiber mats during the treatment. The histopathology studies also suggested the re-epithelialization of the wounds. Hence, these nanomaterials are considered to be environmentally safe scaffolds for efficient tissue regeneration applications.

}, doi = {10.1021/acsabm.9b00354}, author = {Killi, Naresh and Pawar, Anil Tukaram and Gundloori, Rathna V. N.} } @article {46148, title = {Polyhydroxyalkanoates as biomaterials (vol 8, pg 1774, 2017)}, journal = {MedChemComm}, volume = {10}, year = {2019}, month = {APR }, pages = {621}, type = {Correction}, abstract = {

Correction for {\textquoteleft}Polyhydroxyalkanoates as biomaterials{\textquoteright} by Bhagyashri S. Thorat Gadgil et al., Med. Chem. Commun., 2017, 8, 1774-1787.

}, issn = {2040-2503}, doi = {10.1039/c9md90017a}, author = {Gadgil, Bhagyashri S. Thorat and Killi, Naresh and Rathna, Gundloori V. N.} } @article {47583, title = {PEGylated ethyl cellulose micelles as a nanocarrier for drug delivery}, journal = {RSC Advances}, volume = {11}, year = {2021}, month = {NOV }, pages = {30532-30543}, type = {Article}, abstract = {Natural polymers provide a better alternative to synthetic polymers in the domain of drug delivery systems (DDSs) because of their renewability, biocompatibility, and low immunogenicity; therefore, they are being studied for the development of bulk/nanoformulations. Likewise, current methods for engineering natural polymers into micelles are in their infancy, and in-depth studies are required using natural polymers as controlled DDSs. Accordingly, in our present study, a new micellar DDS was synthesized using ethyl cellulose (EC) grafted with polyethylene glycol (PEG); it was characterized, its properties, cell toxicity, and hemocompatibility were evaluated, and its drug release kinetics were demonstrated using doxorubicin (DOX) as a model drug. Briefly, EC was grafted with PEG to form the amphiphilic copolymers EC-PEG1 and EC-PEG2 with varying PEG concentrations, and nano-micelles were prepared with and without the drug (DOX) via a dialysis method; the critical micelle concentrations (CMCs) were recorded to be 0.03 mg mL(-1) and 0.00193 mg mL(-1) for EC-PEG1 and EC-PEG2, respectively. The physicochemical properties of the respective nano-micelles were evaluated via various characterization techniques. The morphologies of the nano-micelles were analyzed via transmission electron microscopy (TEM), and the average size of the nano-micelles was recorded to be similar to 80 nm. In vitro, drug release studies were done for 48 h, where 100\% DOX release was recorded at pH 5.5 and 52\% DOX release was recorded at pH 7.4 from the micelles. In addition, cytotoxicity studies suggested that DOX-loaded micelles were potent in killing MDA-MB-231 and MCF-7 cancer cells, and the blank micelles were non-toxic toward cancerous and normal cells. A cellular uptake study via fluorescence microscopy indicated the internalization of DOX-loaded micelles by cancer cells, delivering the DOX into the cellular compartments. Based on these studies, we concluded that the developed material should be studied further via in vivo studies to understand its potential as a controlled DDS to treat cancer.}, doi = {10.1039/d1ra04242d}, author = {Singam, Amarnath and Killi, Naresh and Patel, Pratikshkumar R. and Gundloori, Rathna V. N.} }