@article {48955,
	title = {Regioselective synthesis of benzannulated [5,6]-oxaspirolactones via Cu(II)-catalyzed cycloisomerization of 2-(5-Hydroxyalkynyl)benzoates},
	journal = {Journal of Organic Chemistry },
	volume = {88},
	year = {2023},
	month = {NOV},
	pages = {16915-16933},
	type = {Article},
	abstract = {<p>Spiroketals and oxaspirolactones are widely found in biologically active natural products, serving as important structural motifs. In this study, we present a Cu-(II)-catalyzed cascade cycloisomerization of 2-(5-hydroxyalkynyl)-benzoates, enabling the regioselective synthesis of benzannulated [5,6]-oxaspirolactones containing an isochromen-1-one moiety. This strategy offers a rapid and efficient approach to access a diverse array of benzannulated [5,6]-oxaspirolactones. The methodology presented here showcases a broad substrate scope, delivering good yields and scalability up to gram scale. The structures of the oxaspirolactones were unequivocally confirmed through single-crystal X-ray analysis and by analogy using H-1 and C-13-{H-1} NMR data.</p>
},
	keywords = {Construction, Isocumarins, Strategies},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.3c01751},
	author = {Thorat, Sagar S. and Shimpi, Sagar P. and Sambherao, Pooja I. and Krishna, Gamidi Rama and Kontham, Ravindar}
}
