@article { ISI:000260843700019, title = {Total synthesis of (+)-isolaurepan}, journal = {Tetrahedron Letters}, volume = {49}, number = {49}, year = {2008}, month = {DEC}, pages = {7012-7014}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A versatile and efficient method for the enantioselective synthesis of 2,7-cis-disubstituted oxepane 1c, (+)-isolaurepan, using oxidative resolution of a secondary alcohol and highly diastereoselective Et(3)SiH/TMSOTf-promoted reductive cyclization of a hydroxy ketone is described. (C) 2008 Elsevier Ltd. All rights reserved.

}, keywords = {Cis-selective cyclization, Cyclic ethers, Isolaurepan, Oxepanes, Oxidative resolution of secondary alcohols}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2008.09.134}, author = {Tripathi, Divya and Kumar, Pradeep} } @article { ISI:000267070700082, title = {Tethered aminohydroxylation route to L-arabino-[2R,3S,4R] and L-xylo-[2R,3S,4S]-C-18-phytosphingosines}, journal = {Tetrahedron Letters}, volume = {50}, number = {26, SI}, year = {2009}, month = {JUL}, pages = {3425-3427}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A concise and highly efficient synthesis of L-arabino-[2R,3S,4R] and L-xylo-[ 2R,3S,4S]-C-18-phytosphingosines has been achieved. The synthetic strategy features the Sharpless kinetic resolution and tethered aminohydroxylation as the key steps. (C) 2009 Elsevier Ltd, All rights reserved.

}, keywords = {Phytosphingosine, Regioselectivity, Sharpless asymmetric kinetic resolution, Sphingolipids, stereoselectivity, Tethered aminohydroxylation}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2009.02.173}, author = {Dubey, Abhishek and Kumar, Pradeep} } @article { ISI:000321573300021, title = {Total synthesis of umuravumbolide and hyptolide through silicon-tethered ring-closing metathesis}, journal = {European Journal of Organic Chemistry}, volume = {2013}, number = {21}, year = {2013}, month = {JUL}, pages = {4586-4593}, publisher = {WILEY-V C H VERLAG GMBH}, address = {BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY}, abstract = {

The total synthesis of umuravumbolide and hyptolide has been achieved in a efficient manner by using temporary silicon-tethered ring-closing metathesis and cross-coupling reactions as key steps. The stereogenic centres were generated by means of proline-catalysed -aminoxylation of aldehydes and Brown{\textquoteright}s asymmetric allylation method.

}, keywords = {lactones, Metathesis, Silanes, synthetic methods, Total synthesis, Wittig reactions}, issn = {1434-193X}, doi = {10.1002/ejoc.201300302}, author = {Chowdhury, Partha Sarathi and Kumar, Pradeep} } @article { ISI:000358734800021, title = {Total synthesis of (+)-petromyroxol via tandem alpha-aminoxylation-allylation and asymmetric dihydroxylation-S(N)2 cyclization approach}, journal = {RSC Advances}, volume = {5}, number = {78}, year = {2015}, month = {JUL}, pages = {63311-63317}, publisher = {ROYAL SOC CHEMISTRY}, address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND}, abstract = {

The total synthesis of (+)-petromyroxol, a tetrahydrofuran (THF)-diol fatty acid, isolated from sea lamprey larvae (Petromyzon marinus) is reported. The present synthesis employs a tandem alpha-aminoxylationallylation, cross metathesis and tandem asymmetric dihydroxylation-S(N)2 cyclization as key steps.

}, issn = {2046-2069}, doi = {10.1039/c5ra10405j}, author = {Nookaraju, U. and Kumar, Pradeep} } @article { ISI:000379493900061, title = {Total synthesis of (-)-(6R,11R,14S)-colletallol via proline catalyzed alpha-aminoxylation and Yamaguchi macrolactonization}, journal = {RSC Advances}, volume = {6}, number = {68}, year = {2016}, month = {JUN}, pages = {63607-63612}, publisher = {ROYAL SOC CHEMISTRY}, address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND}, abstract = {

A simple and efficient synthesis of the 14-membered macrolide (-)-(6R,11R,14S)-colletallol was achieved in a highly diastereoselective manner with high overall yield. The stereogenic centre was generated using a proline catalyzed alpha-aminoxylation reaction and the ring was constructed using Yamaguchi protocol.

}, issn = {2046-2069}, doi = {10.1039/c6ra08484b}, author = {Kauloorkar, Shruti Vandana and Kumar, Pradeep} } @article {44039, title = {Tf2NH-catalyzed 1,6-conjugate addition of vinyl azides with p-quinone methides: a mild and efficient method for the synthesis of β-bis-arylamides}, journal = {Synthesis}, year = {2017}, month = {JAN}, type = {Article}, abstract = {Tf2NH-catalyzed tandem 1,6-conjugate addition/Schmidt type rearrangement using vinyl azides and p-quinone methides to access a variety of β-bis-arylated amides is reported. The method is quick, efficient, mild, and high yielding with broad substrate scope.}, doi = {10.1055/s-0036-1588546}, author = {Rathod, Jayant and Sharma, Brijesh M. and Mali, Pramod S. and Kumar, Pradeep} } @article {43485, title = {Transition metal catalysis-a unique road map in the stereoselective synthesis of 1,3-polyols}, journal = {Organic \& Biomolecular Chemistry}, volume = {15}, year = {2017}, month = {JAN}, pages = {733-761}, abstract = {The present review summarizes recent diverse reactions employed in the formation of 1,3-polyols providing an overview of the mechanistic pathway and the enantioselectivity obtained, in terms of the properties of transition metals directly involved in the catalytic transformations and their interaction with various ligands.}, doi = {10.1039/c6ob01925k}, author = {Kumar, Pradeep and Tripathi, Divya and Sharma, Brijesh M. and Dwivedi, Namrata} } @article {46091, title = {Tf2NH catalyzed 1,6-conjugate addition of 2-hydroxy-p-quinone methides with -functionalized ketones: access to 2,3,4,9-Tetrahydro-1H-xanthenones and 4H-Chromene Derivatives}, journal = {European Journal of Organic Chemistry}, year = {2019}, month = {JUN }, pages = {3127-3133}, type = {Article}, abstract = {

A Bronsted acid catalyzed tandem 1,6-conjugate sequential cycloaddition reaction using 2-hydroxy-p-quinone methides and -functionalized ketones is reported. The method allows xanthenones and chromenes to be accessed in moderate to excellent yield with broad substrate scope, which could be further functionalized to give a versatile set of products.

}, keywords = {-Functionalized ketone, 1, 6-Conjugated addition, Bronsted acid, Chromenes, Xanthenones}, issn = {1434-193X}, doi = {10.1002/ejoc.201900370}, author = {Satbhaiya, Shruti and Khonde, Nilesh S. and Rathod, Jayant and Gonnade, Rajesh and Kumar, Pradeep} } @article {46795, title = {Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials}, journal = {Natural Product Research}, year = {2020}, month = {JUL}, type = {Article; Early Access 2020}, abstract = {

The first total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate (butenolide cinnamate) was achieved using commercially available starting material. The synthesized compound was found to have promising antibacterial activity against Gram-negative strainsEscherichia coli(ATCC 8739),Salmonella typhimurium(ATCC 23564) andPseudomonas aeruginosa(ATCC 19154) with a minimum inhibitory concentration of 2.0 mu g/mL, 1.0 mu g/mL and 2.0 mu g/mL, respectively. Notably, the compound was more potent against Gram-negative test strains than the Gram-positive test strains.

}, keywords = {antibacterial activity, butenolide cinnamate, Total synthesis}, issn = {1478-6419}, doi = {10.1080/14786419.2020.1789979, Early Access Date = JUL 2020}, author = {Said, Madhukar S. and Udavant, Rohini and Sahu, Amit Kumar and Khan, Abujunaid and Nayak, Rashmi and Dastager, Syed G. and Kumar, Pradeep and Gajbhiye, Jayant} } @article {49776, title = {Tetrahydrofuran ring construction through tandem iodocyclizations: synthesis of hagen{\textquoteright}s gland lactones, a pheromone of idea leuconoe , an oxylipid, and related compounds}, journal = {Synlett}, volume = {36}, year = {2025}, month = {SEP}, pages = {2299-2303}, type = {Article}, abstract = {

A simple and efficient common route was developed for the syntheses of tetrahydrofuran-ring-containing natural products such as Hagen{\textquoteright}s gland lactones and their epimers, a pheromone of the butterfly Idea leuconoe, an oxylipid, and some valuable synthons. Brown{\textquoteright}s allylation, cross-metathesis, iodocyclization, and a tandem aminoxylation/allylation were employed as key steps in the syntheses.

}, keywords = {Cross-metathesis, Hagen{\textquoteright}s gland lactone, Iodocyclization, oxylipids, pheromones, tetrahydrofurans}, issn = {0936-5214}, doi = {10.1055/a-2550-1785}, author = {Nookaraju, U. and Danve, Shivam S. and Kumar, Pradeep} }