@article { ISI:000267168600002, title = {Hydrolytic kinetic resolution as an emerging tool in the synthesis of bioactive molecules}, journal = {Synlett}, number = {9}, year = {2009}, month = {JUN}, pages = {1367-1382}, publisher = {GEORG THIEME VERLAG KG}, address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY}, abstract = {

A variety of racemic epoxides mainly derived from terminal olefins, such as aliphatic epoxides, multifuncitonalized epoxides and amine-substituted epoxides, have been successfully resolved into the enantiomerically pure epoxides and diols using Jacobsen{\textquoteright}s hydrolytic kinetic resolution (HKR) method. The chiral epoxides thus prepared were further elaborated by synthetic manipulation to provide a variety Of Compounds of biological interest. A general synthetic strategy for the construction Of S synlanti-1,3-polyol systems using iterative HKR has been developed, which was subsequently utilized in the synthesis of natural products with a broad range of biological activity. The protocol for the 1,3-polyols was also further extended to the synthesis of 1,3-amino alcohols.

}, keywords = {Biological activity, Hydrolytic kinetic resolution, Natural products, synthesis, terminal epoxides}, issn = {0936-5214}, doi = {10.1055/s-0029-1217171}, author = {Kumar, Pradeep and Gupta, Priti} } @article { ISI:000281323300012, title = {Highly selective claisen-schmidt condensation catalyzed by silica chloride under solvent-free reaction conditions}, journal = {Synthetic Communications}, volume = {40}, number = {19}, year = {2010}, month = {AUG}, pages = {PII 926308853}, publisher = {TAYLOR \& FRANCIS INC}, address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA}, abstract = {

Silica chloride serves as a useful catalyst in the cross-aldol condensation, leading to the synthesis of a wide variety of bisarylidene cycloalkanones and chalcones. The catalyst showed high selectivity; self-condensation of ketones was not observed.

}, keywords = {Aldol reaction, arylidene cycloalkanone, Claisen-Schmidt, condensation, silica chloride}, issn = {0039-7911}, doi = {10.1080/00397910903340637}, author = {Hazarkhani, Hassan and Kumar, Pradeep and Kondiram, Kadam Sachin and Gadwal, Ikhlas M. Shafi} } @article { ISI:000323132100073, title = {Highly concise and practical route to clavaminols, sphinganine and (+)-spisulosine via indium mediated allylation of alpha-hydrazino aldehyde and a theoretical insight into the stereochemical aspects of the reaction}, journal = {RSC Advances}, volume = {3}, number = {35}, year = {2013}, month = {JUL}, pages = {15442-15448}, publisher = {ROYAL SOC CHEMISTRY}, address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND}, abstract = {

A conceptually different approach has been employed for the synthesis of 1,2-amino alcohols by proline-catalyzed alpha-amination of aldehyde and one-pot indium mediated allylation of the crude alpha-hydrazino aldehydes. DFT based quantum chemical calculations have been performed to obtain a quantitative explanation of the stereoselectivity of the reaction.

}, issn = {2046-2069}, doi = {10.1039/c3ra43048k}, author = {Pandey, Menaka and Chowdhury, Partha Sarathi and Dutta, Achintya Kumar and Kumar, Pradeep and Pal, Sourav} } @article {43822, title = {Highly active recyclable SBA-15-EDTA-Pd catalyst for Mizoroki-Heck, Stille and Kumada C-C coupling reactions}, journal = {Journal of Porous Materials}, volume = {24}, year = {2017}, month = {AUG}, pages = {837-846}, type = {Article}, abstract = {Highly efficient SBA-15-EDTA-Pd(11) heterogeneous catalyst was synthesized by covalent anchoring Pd-EDTA complex over organo-modified surface of SBA-15. SBA-15-EDTA-Pd(11) catalyst was found to exhibit excellent catalytic activity in appreciable yield for Heck, Stille and Kumada cross-coupling reactions. Catalytic system exhibited excellent activity for completion of reaction, isolation, Pd loading (0.87 mmol\%) and yields of products as compared to earlier reported heterogeneous supported Pd catalysts. Covalently anchored heterogeneous SBA-15-EDTA-Pd(11) catalyst can be recycled for more than five times without noticeable loss in activity and selectivity.}, doi = {10.1007/s10934-016-0323-8}, author = {Rathod, Jayant and Sharma, Priti and Pandey, Punam and Singh, A. P. and Kumar, Pradeep} } @article {45455, title = {Harnessing nucleophilicity of allenol ester with p-quinone methides via gold catalysis: application to the synthesis of diarylmethine-substituted enones}, journal = {Journal of Organic Chemistry}, volume = {83 }, year = {2018}, month = {AUG}, pages = {9353-9363}, type = {Article}, abstract = {A gold(I)-catalyzed protocol for intermolecular 1,6-conjugate addition of nucleophilic allenol ester generated in situ through [3,3]-sigmatropic rearrangement with p-quinone methides (p-QMs) has been developed. The gold catalyst plays a dual role by the pi-acid-triggered activation of alkynes and at the same time as a Lewis acid for activation of p-QMs toward nucleophilic attack. This method enables rapid access to a wide range of densely functionalized diarylmethine-substituted enones, a Morita-Baylis-Hillman (MBH) product with high selectivity, excellent yields, and broad substrate scope.}, doi = {10.1021/acs.joc.8b01294}, author = {Sharma, Brijesh M. and Rathod, Jayant and Gonnade, Rajesh G. and Kumar, Pradeep} } @article {50040, title = {H5IO6, as an efficient reagent for the aromatization of tetrahydro-β-carbolines: total synthesis of norharman, harmane, harmine, kumujian-C, and orthoscuticellines B}, journal = {ChemistrySelect}, volume = {11}, year = {2026}, month = {MAR}, pages = {e04252}, type = {Article}, abstract = {

A new method is reported for the synthesis of beta-carbolines and their derivatives using H5IO6 in DMSO solvent. The method is mild and efficient for oxidative decarboxylation and aromatization of tetrahydro beta-carbolines (TH beta C), resulting in good to excellent yields (70\% to 88\%) of beta-carbolines. This protocol has further been utilized for the synthesis of beta-carbolines based natural products, for examples, norharmane, harmane, harmine, Kumujian-C, and Orthoscuticellines A and B.

}, keywords = {aromatization, beta-carboline, H5IO6, Harmine, orthoscuticellines, Oxidative}, issn = {2365-6549}, doi = {10.1002/slct.202504252}, author = {Sabane, Jagjivan K. and Gaikwad, Sunil V. and Gajbhiye, Jayant M. and Kumar, Pradeep} }