@article {sanjayan, title = {Formal synthesis of herbarumin III}, journal = {Tetrahedron-Asymmetry}, volume = {18}, number = {14}, year = {2007}, month = {JUL}, pages = {1688-1692}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

An enantioselective synthesis of herbarumin III is described employing Jacobsen{\textquoteright}s hydrolytic kinetic resolution and Sharpless asymmetric dihydroxylation as the key steps. (c) 2007 Published by Elsevier Ltd.

}, keywords = {carboxymethyl-cellulase, F. moniliforme, pectate lyase, plant pathogenesis, polygalacturonase, Xylanase}, issn = {0957-4166}, doi = {10.1016/j.tetasy.2007.07.022}, author = {Gupta, Priti and Kumar, Pradeep} } @article { ISI:000265517700038, title = {Facile synthesis of 5,6-dihydro-5-hydroxy-2(1H)-pyridone}, journal = {Tetrahedron Letters}, volume = {50}, number = {20}, year = {2009}, month = {MAY}, pages = {2440-2442}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A short synthesis of 5,6-dihydro-5-hydroxy-2(1H)-pyridone was achieved from L-serine employing Horner-Emmons olefination as the key step. (C) 2009 Elsevier Ltd. All rights reserved.

}, keywords = {alkaloids, Horner-Emmons olefination, L-serine, Pyridone, Z-selectivity}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2009.03.026}, author = {Upadhyay, Puspesh K. and Prasad, Rajendra and Pandey, Menaka and Kumar, Pradeep} } @article { ISI:000271841900023, title = {First asymmetric total synthesis of aspinolide A}, journal = {Tetrahedron Letters}, volume = {50}, number = {50}, year = {2009}, month = {DEC}, pages = {7018-7020}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

The first total synthesis of aspinolide A has been achieved using ring-closing metathesis as a key step. The stereogenic centers were generated by means of hydrolytic kinetic resolution (HKR) of racemic epoxides. (C) 2009 Elsevier Ltd. All rights reserved.

}, keywords = {Decanolides, epoxides, Hydrolytic kinetic resolution, Ring-closing metathesis}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2009.09.151}, author = {Chowdhury, Partha Sarathi and Gupta, Priti and Kumar, Pradeep} } @article { ISI:000312145400009, title = {First total synthesis of seimatopolide B}, journal = {RSC Advances}, volume = {2}, number = {30}, year = {2012}, month = {OCT}, pages = {11231-11234}, publisher = {ROYAL SOC CHEMISTRY}, type = {Article}, address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND}, abstract = {

The first enantioselective total synthesis of seimatopolide B has been achieved, using ring-closing metathesis and DCC (N,N{\textquoteright}-dicyclohexylcarbodiimide) coupling as key steps. The stereogenic centres were generated by means of iterative hydrolytic kinetic resolution (HKR) of racemic epoxides.

}, issn = {2046-2069}, doi = {10.1039/c2ra21838k}, author = {Nookaraju, U. and Harbindu, Anand and Bhise, Ankushkumar D. and Sharma, Brijesh M. and Kumar, Pradeep} } @article { ISI:000307433600011, title = {Formal synthesis of tetrahydrolipstatin and tetrahydroesterastin}, journal = {Tetrahedron-Asymmetry}, volume = {23}, number = {11-12}, year = {2012}, month = {JUN}, pages = {884-890}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A versatile and efficient approach to (3.5,5R)-methyl 3-(benzyloxy)-5-(methoxymethoxy)hexadecanoate, a key chiral building block and a common polyol fragment of the anti-tumor and anti-obesity agents tetrahydrolipstatin 3 and tetrahydroesterastin 4 using both hydrolytic kinetic resolution (HKR) and proline catalyzed sequential alpha-aminoxylation, followed by HWE-olefination reaction is described. (c) 2012 Elsevier Ltd. All rights reserved.

}, issn = {0957-4166}, doi = {10.1016/j.tetasy.2012.05.025}, author = {Tripathi, Divya and Kumar, Pradeep} } @article { ISI:000341883700033, title = {Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity}, journal = {Bioorganic \& Medicinal Chemistry}, volume = {22}, number = {19}, year = {2014}, month = {OCT}, pages = {5506-5512}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A polymer-supported route for the synthesis of sphingosine derivatives is presented based on the C-acylation of polymeric phosphoranylidene acetates with an Fmoc-protected amino acid. The approach enables the flexible variation of the sphingosine tail through a deprotection-decarboxylation sequence followed by E-selective Wittig olefination cleavage. D-Erythro-sphingosine analogs have been synthesized by diastereoselective reduction of the keto group employing LiAlH(O-tBu)(3) as reducing agent. The effect of ceramides and keto-ceramides on the proliferation of three cancer cell lines HEP G-2, PC-12 and HL-60 was investigated and a ceramide containing an aromatic sphingosine tail was identified as being most active. (C) 2014 Elsevier Ltd. All rights reserved.

}, keywords = {Apoptosis, Ceramide, Lipid rafts, Lipids, Sphingosine}, issn = {0968-0896}, doi = {10.1016/j.bmc.2014.07.024}, author = {El-Dahshan, Adeeb and Al-Gharabli, Samer I. and Radetzki, Silke and Al-Tel, Taleb H. and Kumar, Pradeep and Rademann, Joerg} } @article {44654, title = {First total synthesis of the proposed structure of pandangolide 1}, journal = {European Journal of Organic Chemistry}, year = {2018}, month = {JUL}, pages = {3352-3364}, abstract = {

The first total synthesis of the proposed structure of pandangolide 1 is reported. The synthesis was carried out using both an organocatalytic approach and a chiral-pool approach. The required stereochemistry at C-3 and C-5 was installed by using an organocatalytic aldol reaction and a stereoselective ketone reduction. The construction of the 12-membered core was achieved by 2-methyl-6-nitrobenzoic anhydride-mediated Shiina lactonization. The structure of target molecule was confirmed unambiguously by single-crystal X-ray analysis, but the optical rotation and NMR spectroscopic data of the synthetic pandangolide 1 were found to be inconsistent with the natural product.

}, keywords = {lactones, Macrocycles, Natural products, structure elucidation, synthesis design, Total synthesis}, issn = {1434-193X}, doi = {10.1002/ejoc.201800675}, author = {Show, Krishanu and Gonnade, Rajesh G. and Kumar, Pradeep} }