@article { ISI:000371239900016,
	title = {Enantioselective modular total synthesis of macrolides Sch725674 and C-4-epi-Sch725674},
	journal = {European Journal of Organic Chemistry},
	number = {6},
	year = {2016},
	month = {FEB},
	pages = {1215-1226},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
	abstract = {<p>The convergent total synthesis of Sch725674 has been accomplished by starting from (R)-1,2-epoxyheptane and assembling five modules in a highly stereoselective manner to give the final product in 6.6\% overall yield. The same strategy was extended to the synthesis of its C-4 epimer. Key reactions of the synthetic pathway include a Jacobsen hydrolytic kinetic resolution of an epoxide followed by its regioselective opening through a Yamaguchi-Hirao alkynylation, and ring-closing metathesis reaction to furnish the unique 14-membered ring macrolactone. In addition, the influence of protecting groups on the efficiency of the ring-closing metathesis (RCM) macrocyclization has been studied to maximize its yields.</p>},
	keywords = {Asymmetric synthesis, Hydrolytic kinetic resolution, Macrocycles, Metathesis, Natural products},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201501531},
	author = {Sharma, Brijesh M. and Gontala, Arjun and Kumar, Pradeep}
}
@article {44654,
	title = {First total synthesis of the proposed structure of pandangolide 1},
	journal = {European Journal of Organic Chemistry},
	year = {2018},
	month = {JUL},
	pages = {3352-3364},
	abstract = {<p>The first total synthesis of the proposed structure of pandangolide 1 is reported. The synthesis was carried out using both an organocatalytic approach and a chiral-pool approach. The required stereochemistry at C-3 and C-5 was installed by using an organocatalytic aldol reaction and a stereoselective ketone reduction. The construction of the 12-membered core was achieved by 2-methyl-6-nitrobenzoic anhydride-mediated Shiina lactonization. The structure of target molecule was confirmed unambiguously by single-crystal X-ray analysis, but the optical rotation and NMR spectroscopic data of the synthetic pandangolide 1 were found to be inconsistent with the natural product.</p>},
	keywords = {lactones, Macrocycles, Natural products, structure elucidation, synthesis design, Total synthesis},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201800675},
	author = {Show, Krishanu and Gonnade, Rajesh G. and Kumar, Pradeep}
}
