@article { ISI:000371239900016,
	title = {Enantioselective modular total synthesis of macrolides Sch725674 and C-4-epi-Sch725674},
	journal = {European Journal of Organic Chemistry},
	number = {6},
	year = {2016},
	month = {FEB},
	pages = {1215-1226},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
	abstract = {<p>The convergent total synthesis of Sch725674 has been accomplished by starting from (R)-1,2-epoxyheptane and assembling five modules in a highly stereoselective manner to give the final product in 6.6\% overall yield. The same strategy was extended to the synthesis of its C-4 epimer. Key reactions of the synthetic pathway include a Jacobsen hydrolytic kinetic resolution of an epoxide followed by its regioselective opening through a Yamaguchi-Hirao alkynylation, and ring-closing metathesis reaction to furnish the unique 14-membered ring macrolactone. In addition, the influence of protecting groups on the efficiency of the ring-closing metathesis (RCM) macrocyclization has been studied to maximize its yields.</p>},
	keywords = {Asymmetric synthesis, Hydrolytic kinetic resolution, Macrocycles, Metathesis, Natural products},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201501531},
	author = {Sharma, Brijesh M. and Gontala, Arjun and Kumar, Pradeep}
}
@article { ISI:000369072900005,
	title = {N-heterocyclic-carbene-catalyzed regioselective oxidative ring-opening of epoxides with aromatic aldehydes: a facile entry to alpha-acyloxyketones},
	journal = {Asian Journal of Organic Chemistry},
	volume = {5},
	number = {1},
	year = {2016},
	month = {JAN},
	pages = {48-51},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
	abstract = {<p>A high-yielding synthesis of -acyloxyketones using a N-heterocyclic-carbene (NHC)-catalyzed, oxidative ring-opening of epoxides with aromatic aldehydes is described. This regioselective, oxidative process utilizes a N-bromosuccinimide (NBS)/DMSO combination as the oxidant system and Et3N as the base under mild reaction conditions.</p>},
	keywords = {aldehydes, epoxides, halogen oxidants, N-heterocyclic carbenes, oxygen},
	issn = {2193-5807},
	doi = {10.1002/ajoc.201500355},
	author = {Reddi, Rambabu N. and Gontala, Arjun and Prasad, Pragati K. and Sudalai, Arumugam}
}
