@article {48317,
	title = {Accelerated Rauhut-Currier dimerization enabled the synthesis of (+/-)-incarvilleatone and anticancer studies},
	journal = {Beilstein Journal of Organic Chemistry},
	volume = {19},
	year = {2023},
	month = {FEB},
	pages = {204-211},
	type = {Article},
	abstract = {<p>
	The total synthesis of racemic incarvilleatone has been achieved by utilizing unexplored accelerated Rauhut-Currier (RC) dimeriza-tion. The other key steps of the synthesis are oxa-Michael and aldol reactions in a tandem sequence. Racemic incarvilleatone was separated by chiral HPLC and the configuration of each enantiomer was determined by single-crystal X-ray analysis. In addition, a one-pot synthesis of (+/-)-incarviditone has been achieved from rac-rengyolone by using KHMDS as a base. We have also assessed the anticancer activity of all the synthesized compounds in breast cancer cells nonetheless, they exhibited very limited growth suppression activity.</p>
},
	keywords = {dimerization, incarviditone, incarvilleatone, oxa-Michael, Rauhut-Currier},
	issn = {1860-5397},
	doi = {10.3762/bjoc.19.19},
	author = {Kotammagari, Tharun K. and Misra, Sweta and Paul, Sayantan and Kunte, Sunita and Gonnade, Rajesh G. and Santra, Manas K. and Bhattacharya, Asish K.}
}
