@article { ISI:000360510700002,
	title = {Chiral aziridine ring opening: facile synthesis of (R)-modletine and (R)-phenoxybenzamine hydrochloride},
	journal = {Tetrahedron Letters},
	volume = {56},
	number = {38},
	year = {2015},
	month = {SEP},
	pages = {5269-5271},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>A simple and efficient synthesis of chiral drugs (R)-mexiletine 1, an anti-arrhythmic drug and (R)-phenoxybenzamine hydrochloride 2, an anti-hypertensive drug has been described via controlled reductive ring opening of chiral aziridine as a key step. The target compounds 1 and 2 were obtained in overall yields of 34\% and 10.5\%, respectively. (C) 2015 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Aziridine, Mexiletine, Phenoxybenzamine},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2015.07.032},
	author = {Viswanadh, N. and Velayudham, R. and Jambu, S. and Sasikumar, M. and Muthukrishnan, Murugan}
}
@article {48909,
	title = {Efficient synthesis of optically active herbicide (S)-metolachlor via reductive ring opening of 2-methoxymethylaziridine},
	journal = {Arkivoc},
	year = {2023},
	month = {JUL},
	type = {Article},
	abstract = {<p>An efficient synthesis of a well known chiral herbicide, (S)-metolachlor has been described using 2methoxymethylaziridine ring formation and reductive ring opening as key steps using commercially available (R)-epichlorohydrin. The present protocol delivers the required enantiomer of metolachlor in overall yield of 50.8\% and high enantiopurity (\&gt;99\%).</p>
},
	keywords = {Aziridine, Epoxide, Epoxide ring opening, herbicide synthesis, Metolachlor},
	issn = {1551-7004},
	doi = {10.24820/ark.5550190.p011.954},
	author = {Nalla, Viswanadh and Mujahid, Mohammad and Sasikumar, Murugesan and Mujumdar, Prashant and Muthukrishnan, Murugan}
}
