@article { ISI:000284515800005,
	title = {Combined experimental and density functional theory study on the Pd-mediated cycloisomerization of o-alkynylnitrobenzenes - synthesis of isatogens and their evaluation as modulators of ROS-mediated cell death},
	journal = {European Journal of Organic Chemistry},
	number = {31},
	year = {2010},
	month = {NOV},
	pages = {5955-5966},
	publisher = {WILEY-V C H VERLAG GMBH},
	address = {PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY},
	abstract = {<p>Highly selective cycloisomerization of o-alkynylnitrobenzenes, leading to isatogens, has been achieved by employment of a Pd-II complex. This reaction is very general and functional-group-tolerant. The possible mechanism of this reaction was investigated with the help of DFT calculations. Three possible pathways - namely, the addition of the nitro group either in (i) 5-exo-dig or (ii) 6-endo-dig mode and (iii) halopalladation - and subsequent intramolecular events have been considered and studied in detail. These investigations revealed that pathway (i) is the favored route to isatogen formation. A preliminary screening of the available isatogens reveals the 2-alkylisatogens to be novel ROS scavengers capable of inhibiting cellular necroptosis.</p>},
	keywords = {Anthranil, cyclization, Density functional calculations, isatogens, Nitro-alkyne cycloisomerization, Palladium},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201000769},
	author = {Ramana, Chepuri V. and Patel, Pitambar and Vanka, Kumar and Miao, Benchun and Degterev, Alexei}
}
@article {47351,
	title = {Gold-catalysed nitroalkyne cycloisomerization - synthetic utility},
	journal = {Chemical Record},
	volume = {21},
	year = {2021},
	month = {DEC},
	type = {Article},
	abstract = {<p>The gold-catalysed intramolecular redox cyclization of o-alkynylnitrobenzens documented by Professors Naoki Asao and Yoshinori Yamamoto is an important discovery that has opened two complementary research domains. Advancing this cyclization with other metals as well as developing new methods around the products that result from this reaction is one aspect that has seen growing interest. On the other hand, the idea of generating alpha-oxo gold carbenes via oxygen transfer to alkynes has established another important aspect in gold-catalysis. In this account, we will be dealing with the first aspect, which revolves around the internal redox cyclization of nitroalkynes (trivially called as nitroalkyne cycloisomerization), focusing mainly on the gold-complexes and the synthetic methods developed around it from our group and from other groups, and also providing the details of similar transformations documented with other metals so that the complementary reactivity/diversity of these transformations could be appreciated.</p>},
	keywords = {alpha-Oxo Gold Carbene, Anthranil, Gold-catalysis, Internal Redox Cyclization, Isatogen},
	issn = {1527-8999},
	doi = {10.1002/tcr.202100111, Early Access Date = JUN 2021},
	author = {Dhote, Pawan S. and Halnor, Swapnil V. and Ramana, Chepuri V.}
}
