@article {50207,
	title = {Ru(II)-catalyzed C3-H functionalization of indoles with isatogens},
	journal = {Advanced Synthesis \& Catalysis},
	volume = {368},
	year = {2026},
	month = {JUL},
	pages = {e70625},
	type = {Article},
	abstract = {<p>
	A simple methodology for the synthesis of the 2-(1H-indol-3-yl)indolin-3-one core present in various natural products is developed. This method comprises Ru(II)-catalyzed regioselective addition of indole to isatogen, along with N \&amp; horbar;O bond reduction. A range of indolin-3-one compounds incorporating a C2-indolyl unit are synthesized under catalytic conditions in good yields, including the natural products halichrome A and metagenediindole A. With the help of control experiments and density functional theory calculations, a plausible mechanism founded upon the involvement of a bimetallic Ru complex is proposed.</p>
},
	keywords = {2-(1H-indol-3-yl)indolin-3-one, indoles, isatogens, N \& horbar, O bond reduction, pseudoindoxyl natural products},
	issn = {1615-4150},
	doi = {10.1002/adsc.70625},
	author = {Hegde, Chaitra Narayan and Rajeshkumar, Thayalan and Maron, Laurent and Ramana, Chepuri V.}
}
