@article {48205,
	title = {BQ-AurIPr: a redox-active anticancer Au(i) complex that induces immunogenic cell death},
	journal = {Chemical Science},
	volume = {13},
	year = {2022},
	month = {SEP},
	pages = {10779-10785},
	type = {Article},
	abstract = {<p>
	Immunogenic Cell Death (ICD) is a unique cell death mechanism that kills cancer cells while rejuvenating the anticancer immunosurveillance, thereby benefiting the clinical outcomes of various immuno-chemotherapeutic regimens. Herein, we report development of a library of benzo[a]quinolizinium-based Au(i) complexes through an intramolecular amino-auration reaction of pyridino-alkynes. We tested 40 candidates and successfully identified BQ-AurIPr as a novel redox-active Au(i) complex with potent anticancer properties. BQ-AurIPr efficiently triggered generation of DAMPs - the hallmarks of ICD - and was superior in terms of efficiency compared to FDA-approved drugs known to induce ICD. BQ-AurIPr significantly increased immunogenicity of cancer cells enhancing their phagocytosis when co-cultured with immune cells. Our investigation reveals that BQ-AurIPr induces oxidative stress inside mitochondria leading to mitophagy, as the mechanism for immunogenic cell death in A549 cells.</p>
},
	issn = {2041-6520},
	doi = {10.1039/d2sc03756d},
	author = {Mule, Ravindra D. and Kumar, Akhilesh and Sancheti, Shashank P. and Senthilkumar, B. and Kumar, Himanshu and Patil, Nitin T.}
}
